id:"swepub:oai:DiVA.org:su-39341"
Sökning: id:"swepub:oai:DiVA.org:su-39341" > β-Cell Mitochondria...
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- Wikstrom, Jakob D,1978-Stockholms universitet,Wenner-Grens institut,Jan Nedergaard (författare)
β-Cell Mitochondria Exhibit Membrane Potential Heterogeneity That Can Be Altered by Stimulatory or Toxic Fuel Levels
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
- American Diabetes Association,2007
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:su-39341
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-39341URI
- https://doi.org/10.2337/db06-0757DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
Klassifikation
Anmärkningar
- 12 authors
- OBJECTIVE: beta-Cell response to glucose is characterized by mitochondrial membrane potential (Delta Psi) hyperpolarization and the production of metabolites that serve as insulin secretory signals. We have previously shown that glucose-induced mitochondrial hyperpolarization accompanies the concentration-dependent increase in insulin secretion within a wide range of glucose concentrations. This observation represents the integrated response of a large number of mitochondria within each individual cell. However, it is currently unclear whether all mitochondria within a single beta-cell represent a metabolically homogenous population and whether fuel or other stimuli can recruit or silence sizable subpopulations of mitochondria. This study offers insight into the different metabolic states of beta-cell mitochondria. RESULTS: We show that mitochondria display a wide heterogeneity in Delta Psi and a millivolt range that is considerably larger than the change in millivolts induced by fuel challenge. Increasing glucose concentration recruits mitochondria into higher levels of homogeneity, while an in vitro diabetes model results in increased Delta Psi heterogeneity. Exploration of the mechanism behind heterogeneity revealed that temporary changes in Delta Psi of individual mitochondria, ATP-hydrolyzing mitochondria, and uncoupling protein 2 are not significant contributors to Delta Psi heterogeneity. We identified BAD, a proapoptotic BCL-2 family member previously implicated in mitochondrial recruitment of glucokinase, as a significant factor influencing the level of heterogeneity. CONCLUSIONS: We suggest that mitochondrial Delta Psi heterogeneity in beta-cells reflects a metabolic reservoir recruited by an increased level of fuels and therefore may serve as a therapeutic target.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
- mitochondria
- beta cells
- diabetes
- Physiology
- Fysiologi
- fysiologi
- Physiology
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Stockholms universitetWenner-Grens institut (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Diabetes: American Diabetes Association56, s. 2569-25780012-17971939-327X
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