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  • Zhong, Lei (author)

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1 alpha

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • Elsevier BV,2010
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-48907
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-48907URI
  • https://doi.org/10.1016/j.cell.2009.12.041DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • authorCount :20
  • SIRT6 is a member of a highly conserved family of NAD(+)-dependent deacetylases with various roles in metabolism, stress resistance, and life span. SIRT6-deficient mice develop normally but succumb to a lethal hypoglycemia early in life; however, the mechanism underlying this hypoglycemia remained unclear. Here, we demonstrate that SIRT6 functions as a histone H3K9 deacetylase to control the expression of multiple glycolytic genes. Specifically, SIRT6 appears to function as a corepressor of the transcription factor Hif1 alpha, a critical regulator of nutrient stress responses. Consistent with this notion, SIRT6-deficient cells exhibit increased Hif1 alpha activity and show increased glucose uptake with upregulation of glycolysis and diminished mitochondrial respiration. Our studies uncover a role for the chromatin factor SIRT6 as a master regulator of glucose homeostasis and may provide the basis for novel therapeutic approaches against metabolic diseases, such as diabetes and obesity.

Subject headings and genre

  • NATURAL SCIENCES
  • NATURVETENSKAP

Added entries (persons, corporate bodies, meetings, titles ...)

  • D'Urso, Agustina (author)
  • Toiber, Debra (author)
  • Sebastian, Carlos (author)
  • Henry, Ryan E. (author)
  • Vadysirisack, Douangsone D. (author)
  • Guimaraes, Alexander (author)
  • Marinelli, Brett (author)
  • Wikström, Jakob D.Stockholms universitet,Wenner-Grens institut (author)
  • Nir, Tomer (author)
  • Clish, Clary B. (author)
  • Vaitheesvaran, Bhavapriya (author)
  • Iliopoulos, Othon (author)
  • Kurland, Irwin (author)
  • Dor, Yuval (author)
  • Weissleder, Ralph (author)
  • Shirihai, Orian S. (author)
  • Ellisen, Leif W. (author)
  • Espinosa, Joaquin M. (author)
  • Mostoslavsky, Raul (author)
  • Stockholms universitetWenner-Grens institut (creator_code:org_t)

Related titles

  • In:Cell: Elsevier BV140:2, s. 280-2930092-86741097-4172

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