Search: L773:1873 1708 OR L773:0890 6238 >
Tissue distribution...
Tissue distribution of S-35-labelled perfluorooctane sulfonate (PFOS) in C57Bl/6 mice following late gestational exposure
-
- Borg, D. (author)
- Karolinska Institutet
-
- Bogdanska, J. (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholms Universitet
-
- Sundström, Maria (author)
- Stockholms universitet,Avdelningen för miljökemi,Stockholms Universitet
-
show more...
-
- Nobel, S. (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholms Universitet
-
- Håkansson, H. (author)
- Karolinska Institutet
-
- Bergman, Åke (author)
- Stockholms universitet,Avdelningen för miljökemi,Stockholms Universitet
-
- DePierre, J. W. (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholms Universitet
-
- Halldin, Krister (author)
- Karolinska Institutet
-
- Bergström, Ulrika, 1969- (author)
- Uppsala universitet,Ekotoxikologi
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- English.
-
In: Reproductive Toxicology. - : Elsevier BV. - 0890-6238 .- 1873-1708. ; 30:4, s. 558-565
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Exposure of rodents in utero to perfluorooctane sulfonate (PFOS) impairs perinatal development and survival Following intravenous or gavage exposure of C57Bl/6 mouse dams on gestational day (GD) 16 to S-35-PFOS (12 5 mg/kg) we determined the distribution in dams fetuses (GD18 and GD20) and pups (postnatal day 1 PND1) employing whole-body autoradiography and liquid scintillation counting In dams levels were highest in liver and lungs After placental transfer S-35-PFOS was present on GD18 at 2-3 times higher levels in lungs liver and kidneys than in maternal blood In PND1 pups levels in lungs were significantly higher than in GD18 fetuses A heterogeneous distribution of S-35-PFOS was observed in brains of fetuses and pups with levels higher than in maternal brain This first demonstration of substantial localization of PFOS to both perinatal and adult lungs is consistent with evidence describing the lung as a target for the toxicity of PFOS at these ages.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Perfluorooctane sulfonate (PFOS)
- Perfluoroalkylated compounds (PFCs)
- Autoradiography
- Liquid scintillation counting
- Perinatal
- Tissue distribution
- C57Bl/6 mouse
- Biology
- Biologi
- Toxicology
- Toxikologi
- toxikologi
- Toxicology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database