L773:0171 9335
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- Johnsson, Anna-Karin,1980-Stockholms universitet,Avdelningen för cellbiologi (author)
Microtubule-dependent localization of profilin I mRNA to actin polymerization sites in serum-stimulated cells
- Article/chapterEnglish2010
Publisher, publication year, extent ...
- Elsevier BV,2010
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:su-56880
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-56880URI
- https://doi.org/10.1016/j.ejcb.2009.10.020DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Specific localization of messenger RNA (mRNA) appears to be a general mechanism to accumulate certain proteins to subcellular compartments for participation in local processes, thereby maintaining cell polarity under strict spatiotemporal control. Transportation of mRNA with associated protein components (RNP granules) by the actin microfilament or the microtubule systems is one important mechanism to achieve this locally distributed protein production. Here we provide evidence for a microtubule-dependent localization of mRNA encoding the actin regulatory protein profilin to sites in mouse embryonic fibroblasts, which express enhanced actin polymerization.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- Actin polymerization
- Profilin
- mRNA localization
- FISH
- microtubules
- Cell biology
- Cellbiologi
- Cell Biology
- cellbiologi
Added entries (persons, corporate bodies, meetings, titles ...)
- Karlsson, RogerStockholms universitet,Avdelningen för cellbiologi(Swepub:su)rkarl (author)
- Stockholms universitetAvdelningen för cellbiologi (creator_code:org_t)
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- In:European Journal of Cell Biology: Elsevier BV89:5, s. 394-4010171-93351618-1298
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