Covalent anchoring of a racemization catalyst to CALB-beads : towards dual immobilization of DKR catalysts

• The preparation of a heterogeneous bifunctional catalytic system, combining the catalytic properties of an organometallic catalyst (racemization) with those of an enzyme (enantioselective acylation) is described. A novel ruthenium phosphonate inhibitor was synthesized and covalently anchored to a lipase immobilized on a solid support (CALB, Novozym® 435). The immobilized bifunctional catalytic system showed activity in both racemization of (S)-1-phenylethanol and selective acylation of 1-phenylethanol.

Subject headings

NATURVETENSKAP  -- Kemi -- Organisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Organic Chemistry (hsv//eng)

Keyword

Bifunctional catalytic system

Metalloenzyme

DKR

Lipases

Heterogeneous catalysis

Organic chemistry

Organisk kemi

Publication and Content Type

ref (subject category)

art (subject category)