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Design, synthesis a...
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Bäck, MarcusLinköpings universitet,Organisk Kemi,Tekniska högskolan
(author)
Design, synthesis and SAR of potent statine-based BACE-1 inhibitors : Exploration of P1 phenoxy and benzyloxy residues
- Article/chapterEnglish2008
Publisher, publication year, extent ...
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Elsevier BV,2008
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:su-57900
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-57900URI
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https://doi.org/10.1016/j.bmc.2008.09.041DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17848URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-102900URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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authorCount :11
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Several BACE-1 inhibitors with low nanomolar level activities, encompassing a statine-based core structure with phenyloxymethyl- and benzyloxymethyl residues in the P1 position, are presented. The novel P1 modi. cation introduced to allow the facile exploration of the S1 binding pocket of BACE-1, delivered highly promising inhibitors.
Subject headings and genre
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Alzheimer's disease
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BACE-1 inhibitors
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P1 modifications
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Peptidomimetics
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NATURAL SCIENCES
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NATURVETENSKAP
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MEDICINE
Added entries (persons, corporate bodies, meetings, titles ...)
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Nyhlen, JonasLinköpings universitet,Organisk Kemi,Tekniska högskolan
(author)
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Kvarnström, IngemarLinköpings universitet,Organisk Kemi,Tekniska högskolan(Swepub:liu)ingkv34
(author)
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Appelgren, SaraMedivir AB, Lunastigen 7, S-141 44 Huddinge, Sweden
(author)
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Borkakoti, NeeraMedivir AB, Lunastigen 7, S-141 44 Huddinge, Sweden
(author)
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Jansson, KatarinaMedivir AB, Lunastigen 7, S-141 44 Huddinge, Sweden
(author)
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Lindberg, JimmyMedivir AB, Lunastigen 7, S-141 44 Huddinge, Sweden
(author)
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Nystrom, SusanneMedivir AB, Lunastigen 7, S-141 44 Huddinge, Sweden
(author)
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Hallberg, AndersUppsala universitet,Avdelningen för organisk farmaceutisk kemi(Swepub:uu)andehall
(author)
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Rosenquist, AsaLinköpings universitet,Organisk Kemi,Tekniska högskolan,Medivir AB, Lunastigen 7, S-141 44 Huddinge, Sweden
(author)
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Samuelsson, BertilStockholms universitet,Institutionen för organisk kemi,Medivir AB, Lunastigen 7, S-141 44 Huddinge, Sweden/Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-10691 Stockholm, Sweden
(author)
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Rosenquist, Sa
(author)
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Linköpings universitetOrganisk Kemi
(creator_code:org_t)
Related titles
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In:Bioorganic & Medicinal Chemistry: Elsevier BV16:21, s. 9471-94860968-08961464-3391
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- By the author/editor
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Bäck, Marcus
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Nyhlen, Jonas
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Kvarnström, Inge ...
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Appelgren, Sara
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Borkakoti, Neera
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Jansson, Katarin ...
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Lindberg, Jimmy
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Nystrom, Susanne
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Hallberg, Anders
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Rosenquist, Asa
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Samuelsson, Bert ...
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Rosenquist, Sa
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- Articles in the publication
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Bioorganic & Med ...
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Stockholm University
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Linköping University
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Uppsala University