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Serum total cholest...
Serum total cholesterol, statins and cognition in non-demented elderly
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- Olomon, A. S. (author)
- Karolinska Institutet
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- Kareholt, I (author)
- Karolinska Institutet,Stockholms universitet,Institutionen för socialt arbete - Socialhögskolan
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- Ngandu, T. (author)
- Karolinska Institutet
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Wolozin, B. (author)
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MacDonald, S. W. S. (author)
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- Winblad, B. (author)
- Karolinska Institutet
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Nissinen, A. (author)
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Tuomilehto, J. (author)
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Soininen, H. (author)
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- Kivipelto, M. (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
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In: Neurobiology of Aging. - : Elsevier BV. - 0197-4580 .- 1558-1497. ; 30:6, s. 1006-1009
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: The association between serum total cholesterol (TC), lipid-lowering drugs and cognition in the elderly is currently controversial. Objective: To investigate the relationship between TC, lipid-lowering drugs and cognitive functions in non-demented elderly. Design and Setting: Participants of the Cardiovascular risk factors, aging and dementia (CAIDE) study were derived from random, population-based samples previously studied in 1972, 1977, 1982 or 1987. Analyses are based on 1382 non-demented participants re-examined in 1998 after an average follow-up of 21 years. Results: High midlife TC was associated with poorer late-life episodic memory and category fluency. TC decreased in most individuals over time. A more pronounced decrease was related to poorer late-life episodic memory and psychomotor speed, but not if subjects used statins. Conclusions: The TC-cognition relationship seems bidirectional. High midlife TC is associated with poorer late-life cognition, but decreasing TC after midlife may reflect poorer cognitive status. Statins may be beneficial for cognition in non-demented elderly.
Keyword
- Statins
- Midlife cholesterol
- Changes in cholesterol
- Cognition
- Social sciences
- Socialvetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Olomon, A. S.
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Kareholt, I
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Ngandu, T.
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Wolozin, B.
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MacDonald, S. W. ...
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Winblad, B.
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show more...
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Nissinen, A.
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Tuomilehto, J.
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Soininen, H.
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Kivipelto, M.
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show less...
- Articles in the publication
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Neurobiology of ...
- By the university
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Stockholm University
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Karolinska Institutet