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The complement regu...
The complement regulator CD46 is bactericidal to Helicobacter pylori and blocks urease activity
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- Basmarke-Wehelie, Rahma (author)
- Stockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi,Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Swede
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- Sjölinder, Hong (author)
- Stockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi,Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Swede
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- Jurkowski, Wiktor (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden
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- Elofsson, Arne (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden
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- Arnqvist, Anna (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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- Engstrand, Lars (author)
- Karolinska Institutet,Swedish Institute for Infectious Disease Control, Karolinska Institutet, Solna, Sweden
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- Hagner, Matthias (author)
- Stockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi,Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden
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- Wallin, Elin (author)
- Stockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi,Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden
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- Guan, Na (author)
- Stockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi,Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden
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- Kuranasekera, Hasanthi (author)
- Stockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi,Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden
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- Aro, Helena (author)
- Stockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi,Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden
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- Jonsson, Ann-Beth (author)
- Stockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi,Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden
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(creator_code:org_t)
- Baltimore : Elsevier BV, 2011
- 2011
- English.
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In: Gastroenterology. - Baltimore : Elsevier BV. - 0016-5085 .- 1528-0012. ; 141:3, s. 918-928
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Abstract
Subject headings
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- BACKGROUND & AIMS: CD46 is a C3b/C4b binding complement regulator and a receptor for several human pathogens. We examined the interaction between CD46 and Helicobacter pylori (a bacterium that colonizes the human gastric mucosa and causes gastritis), peptic ulcers, and cancer.METHODS: Using gastric epithelial cells, we analyzed a set of H pylori strains and mutants for their ability to interact with CD46 and/or influence CD46 expression. Bacterial interaction with full-length CD46 and small CD46 peptides was evaluated by flow cytometry, fluorescence microscopy, enzyme-linked immunosorbent assay, and bacterial survival analyses.RESULTS: H pylori infection caused shedding of CD46 into the extracellular environment. A soluble form of CD46 bound to H pylori and inhibited growth, in a dose- and time-dependent manner, by interacting with urease and alkyl hydroperoxide reductase, which are essential bacterial pathogenicity-associated factors. Binding of CD46 or CD46-derived synthetic peptides blocked the urease activity and ability of bacteria to survive in acidic environments. Oral administration of one CD46 peptide eradicated H pylori from infected mice.CONCLUSIONS: CD46 is an antimicrobial agent that can eradicate H pylori. CD46 peptides might be developed to treat H pylori infection.
Subject headings
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- AhpC
- Stomach Cancer
- Bacterial Infection
- mikrobiologi
- Microbiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Basmarke-Wehelie ...
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Sjölinder, Hong
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Jurkowski, Wikto ...
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Elofsson, Arne
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Arnqvist, Anna
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Engstrand, Lars
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Hagner, Matthias
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Wallin, Elin
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Guan, Na
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Kuranasekera, Ha ...
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Aro, Helena
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Jonsson, Ann-Bet ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
- Articles in the publication
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Gastroenterology
- By the university
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Stockholm University
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Karolinska Institutet
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Umeå University