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  • Basmarke-Wehelie, RahmaStockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi,Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Swede (author)

The complement regulator CD46 is bactericidal to Helicobacter pylori and blocks urease activity

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • Baltimore :Elsevier BV,2011
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-63669
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-63669URI
  • https://doi.org/10.1053/j.gastro.2011.05.009DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:123152816URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-47390URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND & AIMS: CD46 is a C3b/C4b binding complement regulator and a receptor for several human pathogens. We examined the interaction between CD46 and Helicobacter pylori (a bacterium that colonizes the human gastric mucosa and causes gastritis), peptic ulcers, and cancer.METHODS: Using gastric epithelial cells, we analyzed a set of H pylori strains and mutants for their ability to interact with CD46 and/or influence CD46 expression. Bacterial interaction with full-length CD46 and small CD46 peptides was evaluated by flow cytometry, fluorescence microscopy, enzyme-linked immunosorbent assay, and bacterial survival analyses.RESULTS: H pylori infection caused shedding of CD46 into the extracellular environment. A soluble form of CD46 bound to H pylori and inhibited growth, in a dose- and time-dependent manner, by interacting with urease and alkyl hydroperoxide reductase, which are essential bacterial pathogenicity-associated factors. Binding of CD46 or CD46-derived synthetic peptides blocked the urease activity and ability of bacteria to survive in acidic environments. Oral administration of one CD46 peptide eradicated H pylori from infected mice.CONCLUSIONS: CD46 is an antimicrobial agent that can eradicate H pylori. CD46 peptides might be developed to treat H pylori infection.

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  • Sjölinder, HongStockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi,Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Swede(Swepub:su)hwan (author)
  • Jurkowski, WiktorStockholms universitet,Institutionen för biokemi och biofysik,Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden (author)
  • Elofsson, ArneStockholms universitet,Institutionen för biokemi och biofysik,Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden(Swepub:su)aelof (author)
  • Arnqvist, AnnaUmeå universitet,Institutionen för medicinsk kemi och biofysik(Swepub:umu)anar0001 (author)
  • Engstrand, LarsKarolinska Institutet,Swedish Institute for Infectious Disease Control, Karolinska Institutet, Solna, Sweden (author)
  • Hagner, MatthiasStockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi,Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden (author)
  • Wallin, ElinStockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi,Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden (author)
  • Guan, NaStockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi,Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden (author)
  • Kuranasekera, HasanthiStockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi,Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden (author)
  • Aro, HelenaStockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi,Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden(Swepub:su)haro (author)
  • Jonsson, Ann-BethStockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi,Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden(Swepub:su)anjons (author)
  • Stockholms universitetInstitutionen för genetik, mikrobiologi och toxikologi (creator_code:org_t)

Related titles

  • In:GastroenterologyBaltimore : Elsevier BV141:3, s. 918-9280016-50851528-0012

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