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ELOVL2 controls the...
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Zadravec, DamirStockholms universitet,Avdelningen för fysiologi
(författare)
ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis : a prerequisite for male fertility and sperm maturation in mice
- Artikel/kapitelEngelska2011
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LIBRIS-ID:oai:DiVA.org:su-65642
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-65642URI
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https://doi.org/10.1194/jlr.M011346DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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authorCount :8
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ELOVL2 is a member of the mammalian microsomal ELOVL fatty acid enzyme family, involved in the elongation of very long-chain fatty acids including PUFAs required for various cellular functions in mammals. Here, we used ELOVL2-ablated (Elovl2(-/-)) mice to show that the PUFAs with 24-30 carbon atoms of the ω-6 family in testis are indispensable for normal sperm formation and fertility in male mice. The lack of Elovl2 was associated with a complete arrest of spermatogenesis, with seminiferous tubules displaying only spermatogonia and primary spermatocytes without further germinal cells. Furthermore, based on acyl-CoA profiling, heterozygous Elovl2(+/-) male mice exhibited haploinsufficiency, with reduced levels of C28:5 and C30:5n-6 PUFAs, which gave rise to impaired formation and function of haploid spermatides. These new insights reveal a novel mechanism involving ELOVL2-derived PUFAs in mammals and previously unrecognized roles for C28 and C30 n-6 PUFAs in male fertility. In accordance with the function suggested for ELOVL2, the Elovl2(-/-) mice show distorted levels of serum C20 and C22 PUFAs from both the n-3 and the n-6 series. However, dietary supplementation with C22:6n-3 could not restore male fertility to Elovl2(+/-) mice, suggesting that the changes in n-6 fatty acid composition seen in the testis of the Elovl2(+/-) mice, cannot be compensated by increased C22:6n-3 content.
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Tvrdik, Petr
(författare)
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Guillou, Hervé
(författare)
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Haslam, Richard
(författare)
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Kobayashi, TsutomuStockholms universitet,Wenner-Grens institut
(författare)
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Napier, Johnathan A
(författare)
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Capecchi, Mario R
(författare)
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Jacobsson, AndersStockholms universitet,Avdelningen för fysiologi(Swepub:su)anjac
(författare)
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Stockholms universitetAvdelningen för fysiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Lipid Research52:2, s. 245-2550022-22751539-7262
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