WFRF:(Clinton D)
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- Cumpstey, IanStockholms universitet,Institutionen för organisk kemi (author)
Synthesis and alpha-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis
- Article/chapterEnglish2011
Publisher, publication year, extent ...
- Elsevier BV,2011
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:su-67274
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-67274URI
- https://doi.org/10.1016/j.bmcl.2011.07.046DOI
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- Language:English
- Summary in:English
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Notes
- authorCount :5
- Valienol-derived allylic C-1 bromides have been used as carbaglycosyl donors for alpha-xylo configured valienamine pseudodisaccharide synthesis. We synthesised valienamine analogues of the Glc(alpha 1 -> 3)Glc and Glc(alpha 1 -> 3) Man disaccharides representing the linkages cleaved by alpha-Glucosidase II in N-glycan biosynthesis. These (N1 -> 3)-linked pseudodisaccharides were found to have some alpha-Glucosidase II inhibitory activity, while two other (N1 -> 6)-linked valienamine pseudodisaccharides failed to inhibit the enzyme. (C)
Subject headings and genre
- alpha-Glucosidase II
- Glycosidase inhibitors
- Valienamine
- Pseudodisaccharides
- N-Glycans
Added entries (persons, corporate bodies, meetings, titles ...)
- Ramstadius, Clinton (author)
- Borbas, K. EszterStockholms universitet,Institutionen för organisk kemi(Swepub:su)eborb (author)
- Alonzi, Dominic S. (author)
- Butters, Terry D. (author)
- Stockholms universitetInstitutionen för organisk kemi (creator_code:org_t)
Related titles
- In:Bioorganic & Medicinal Chemistry Letters: Elsevier BV21:18, s. 5219-52230960-894X1464-3405
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