WFRF:(Welchman David P.)
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- Zaidman-Remy, Anna (author)
Drosophila Immunity : Analysis of PGRP-SB1 Expression, Enzymatic Activity and Function
- Article/chapterEnglish2011
Publisher, publication year, extent ...
- 2011-02-18
- Public Library of Science (PLoS),2011
- electronicrdacarrier
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- LIBRIS-ID:oai:DiVA.org:su-67510
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-67510URI
- https://doi.org/10.1371/journal.pone.0017231DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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- authorCount :9
- Peptidoglycan is an essential and specific component of the bacterial cell wall and therefore is an ideal recognition signature for the immune system. Peptidoglycan recognition proteins (PGRPs) are conserved from insects to mammals and able to bind PGN (non-catalytic PGRPs) and, in some cases, to efficiently degrade it (catalytic PGRPs). In Drosophila, several non-catalytic PGRPs function as selective peptidoglycan receptors upstream of the Toll and Imd pathways, the two major signalling cascades regulating the systemic production of antimicrobial peptides. Recognition PGRPs specifically activate the Toll pathway in response to Lys-type peptidoglycan found in most Gram-positive bacteria and the Imd pathway in response to DAP-type peptidoglycan encountered in Gram-positive bacilli-type bacteria and in Gram-negative bacteria. Catalytic PGRPs on the other hand can potentially reduce the level of immune activation by scavenging peptidoglycan. In accordance with this, PGRP-LB and PGRP-SC1A/B/2 have been shown to act as negative regulators of the Imd pathway. In this study, we report a biochemical and genetic analysis of PGRP-SB1, a catalytic PGRP. Our data show that PGRP-SB1 is abundantly secreted into the hemolymph following Imd pathway activation in the fat body, and exhibits an enzymatic activity towards DAP-type polymeric peptidoglycan. We have generated a PGRP-SB1/2 null mutant by homologous recombination, but its thorough phenotypic analysis did not reveal any immune function, suggesting a subtle role or redundancy of PGRP-SB1/2 with other molecules. Possible immune functions of PGRP-SB1 are discussed.
Subject headings and genre
- NATURVETENSKAP Biologi hsv//swe
- NATURAL SCIENCES Biological Sciences hsv//eng
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- Poidevin, Mickael (author)
- Herve, Mireille (author)
- Welchman, David P. (author)
- Paredes, Juan C. (author)
- Fahlander, CarinaStockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi (author)
- Steiner, HåkanStockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi(Swepub:su)stein (author)
- Mengin-Lecreulx, Dominique (author)
- Lemaitre, Bruno (author)
- Stockholms universitetInstitutionen för genetik, mikrobiologi och toxikologi (creator_code:org_t)
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- In:PLOS ONE: Public Library of Science (PLoS)6:2, s. e17231-1932-6203
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