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Sökning: L773:1879 355X > (2010-2014) > Secondary malignanc...

  • Daşu, AlexandruUmeå universitet,Radiofysik,Umeå University, Sweden (författare)

Secondary malignancies from prostate cancer radiation treatment : a risk analysis of the influence of target margins and fractionation patterns

  • Artikel/kapitelEngelska2011

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2011
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:su-67927
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-67927URI
  • https://doi.org/10.1016/j.ijrobp.2009.12.004DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-39615URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-71978URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:121940072URI
  • https://lup.lub.lu.se/record/1878017URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-511001URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • authorCount :5
  • PURPOSE: This study explores the implications for cancer induction of treatment details such as fractionation, planning target volume (PTV) definition, and interpatient variations, which are relevant for the radiation treatment of prostate carcinomas.METHODS AND MATERIALS: Treatment planning data from 100 patients have been analyzed with a risk model based on the United Nations Scientific Committee on the Effects of Atomic Radiation competition model. The risk model can account for dose heterogeneity and fractionation effects characteristic for modern radiotherapy. Biologically relevant parameters from clinical and experimental data have been used with the model.RESULTS: The results suggested that changes in prescribed dose could lead to a modification of the risks for individual organs surrounding the clinical target volume (CTV) but that the total risk appears to be less affected by changes in the target dose. Larger differences are observed for modifications of the margins between the CTV and the PTV because these have direct impact onto the dose level and dose heterogeneity in the healthy tissues surrounding the CTV. Interpatient anatomic variations also have to be taken into consideration for studies of the risk for cancer induction from radiotherapy.CONCLUSIONS: The results have shown the complex interplay between the risk for secondary malignancies, the details of the treatment delivery, and the patient heterogeneity that may influence comparisons between the long-term effects of various treatment techniques. Nevertheless, absolute risk levels seem very small and comparable to mortality risks from surgical interventions, thus supporting the robustness of radiation therapy as a successful treatment modality for prostate carcinomas.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Toma-Dasu, IulianaKarolinska Institutet,Stockholms universitet,Medicinsk strålningsfysik (tills m KI),Stockholm University and Karolinska Institutet(Swepub:su)iuda0736 (författare)
  • Franzén, LarsUmeå universitet,Onkologi,Umeå University, Sweden(Swepub:umu)lafr0004 (författare)
  • Widmark, AndersUmeå universitet,Onkologi,Umeå University, Sweden(Swepub:umu)anwi0004 (författare)
  • Nilsson, PerLund University,Lunds universitet,Umeå universitet,Radiofysik,Umeå University, Sweden; Lund University, Sweden,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)rafy-per (författare)
  • Umeå universitetRadiofysik (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International Journal of Radiation Oncology, Biology, Physics: Elsevier BV79:3, s. 738-7460360-30161879-355X

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