WFRF:(Rieckmann Anna)
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- Rieckmann, AnnaStockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (author)
Caudate Dopamine D1 Receptor Density Is Associated with Individual Differences in Frontoparietal Connectivity during Working Memory
- Article/chapterEnglish2011
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- Society for Neuroscience,2011
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:su-70388
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-70388URI
- https://doi.org/10.1523/JNEUROSCI.3114-11.2011DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102522URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:123393770URI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- authorCount :4
- We assess the relationship of age-related losses in striatal D1 receptor densities to age-related reductions in functional connectivity between spatially distinct cortical regions in healthy human participants. Previous neuroimaging studies have reported age-related differences in functional connectivity of the frontoparietal working memory network and the default mode network during task performance. We used functional magnetic resonance imaging and seed-based connectivity (right dorsolateral and medial prefrontal cortex) to extend these findings: Anterior-posterior connectivity of both these functional networks was reduced in older (65-75 years, n = 18) compared with younger (20-30 years, n = 19) adults, whereas bilateral connectivity in prefrontal cortex was increased in older adults. Positron emission tomography with the D1 receptor ligand [(11)C]SCH23390 was used to assess caudate D1 receptor density in the same sample. Older adults showed significantly reduced caudate D1 receptor density compared to the younger adults. Of key interest, partial correlations showed that individual differences in caudate D1 receptor density were positively associated with individual differences in dorsolateral prefrontal connectivity to right parietal cortex (BA40) and negatively with medial prefrontal connectivity to right parietal cortex (BA40 and postcentral gyrus), after controlling for age. We found no correlation of caudate D1 receptor density with anterior-posterior coupling within the default mode network or with bilateral frontal connectivity. These results are consistent with animal work that has identified a role for caudate D1 receptors in mediating information transfer between prefrontal areas and parietal cortex.
Subject headings and genre
- SAMHÄLLSVETENSKAP Psykologi hsv//swe
- SOCIAL SCIENCES Psychology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
- cognition
- aging
- brain imaging
- Psychology
- Psykologi
- Psychology
- psykologi
Added entries (persons, corporate bodies, meetings, titles ...)
- Karlsson, SariKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (author)
- Fischer, HåkanKarolinska Institutet,Stockholms universitet,Psykologiska institutionen(Swepub:su)hkfi4392 (author)
- Bäckman, LarsKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (author)
- Stockholms universitetCentrum för forskning om äldre och åldrande (ARC), (tills m KI) (creator_code:org_t)
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- In:Journal of Neuroscience: Society for Neuroscience31:40, s. 14284-142900270-64741529-2401
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