SwePub
Sök i LIBRIS databas

  Utökad sökning

L773:1398 5647 OR L773:1399 5618
 

Sökning: L773:1398 5647 OR L773:1399 5618 > (2010-2014) > Evidence for the in...

  • Ceulemans, Shana (författare)

Evidence for the involvement of the glucocorticoid receptor gene in bipolar disorder in an isolated northern Swedish population

  • Artikel/kapitelEngelska2011

Förlag, utgivningsår, omfång ...

  • 2011-11-15
  • Malden, USA :John Wiley & Sons,2011
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:su-70450
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-70450URI
  • https://doi.org/10.1111/j.1399-5618.2011.00960.xDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-50696URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • authorCount :9 This work was funded in part by the University of Antwerp, the Fund for Scientific Research-Flanders (FWO-F), the Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT), the Swedish Research Council (2006–4472 and 2009–5269), the Medical Faculty, Umeå University, and the County Councils of Västerbotten and Norrbotten, Sweden. None of the funding agencies had any further role in the study design, in collection, analysis, or interpretation of the data, in writing of the report, or in the decision to submit the paper for publication. SC holds a Ph.D. fellowship from IWT and SC is a senior Clinical Investigator of FWO-F. The authors are grateful to the patients and their relatives for their cooperation and participation in this research study. We acknowledge the contribution of the personnel of the VIB Genetic Service Facility (http://www.vibgeneticservicefacility.be) for the genetic analyses. Research nurse Eva Lundberg is acknowledged for her help and expertise in clinically evaluating the bipolar disorder patient sample.
  • Objectives: Dysfunction of the hypothalamus-pituitary-adrenal (HPA) axis is one of the most consistent findings in the pathophysiology of mood disorders. The potential role of genes related to HPA axis function has been investigated extensively in major depression. However, in bipolar disorder (BPD) such studies are scarce. We performed a systematic HapMap-based association study of six genes crucial for HPA axis function in relation to BPD. Methods: Haplotype tagging single nucleotide polymorphisms (htSNPs) were selected in order to identify all haplotypes with a frequency of more than 1% in the genes encoding the glucocorticoid receptor (GR), mineralocorticoid receptor (MR), corticotrophin releasing hormone receptor 1 (CRH-R1) and 2 (CRH-R2), CRH binding protein (CRH-BP), and FK binding protein 5 (FKBP5). This resulted in a total selection of 225 SNPs that were genotyped and analyzed in 309 BPD patients and 364 matched control individuals all originating from an isolated northern Swedish population. Results: Consistent evidence for an association with BPD was found for NR3C1, the gene encoding GR. Almost all SNPs in two adjacent haplotype blocks contributed to the positive signal, comprised of significant single marker, sliding window, and haplotype-specific p-values. All these results point to a moderately frequent (10–15%) susceptibility haplotype covering the entire coding region and 3? untranslated region (UTR) of NR3C1. Conclusions: This study contributes to the growing evidence for a role of the glucocorticoid receptor gene (NR3C1) in vulnerability to mood disorders, and BPD in particular, and warrants further in vitro investigation of the at-risk haplotypes with respect to disease etiology. However, this association might be restricted to this specific population, as it is observed in a rather small sample from an isolated population without replication, and data from large meta-analyses for genome-wide association studies in BPD do not show the GR as a very strong candidate.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • De Zutter, Sonia (författare)
  • Heyrman, Lien (författare)
  • Norrback, Karl-FredrikUmeå universitet,Psykiatri(Swepub:umu)kaknok96 (författare)
  • Nordin, AnnelieUmeå universitet,Psykiatri(Swepub:umu)anenon01 (författare)
  • Nilsson, Lars-GöranStockholms universitet,Psykologiska institutionen(Swepub:su)lgn (författare)
  • Adolfsson, RolfUmeå universitet,Psykiatri(Swepub:umu)road0001 (författare)
  • Del-Favero, Jurgen (författare)
  • Claes, Stephan (författare)
  • Umeå universitetPsykiatri (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Bipolar DisordersMalden, USA : John Wiley & Sons13:7-8, s. 614-6231398-56471399-5618

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy