SwePub
Sök i LIBRIS databas

  Extended search

id:"swepub:oai:DiVA.org:su-74225"
 

Search: id:"swepub:oai:DiVA.org:su-74225" > Short Telomeres in ...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Wikgren, Mikael,1981-Umeå universitet,Psykiatri,Umeå University (author)

Short Telomeres in Depression and the General Population Are Associated with a Hypocortisolemic State

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • New York :Elsevier,2012
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-74225
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-74225URI
  • https://doi.org/10.1016/j.biopsych.2011.09.015DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-49384URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-75101URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The research was funded by the Swedish Research Council (Grants 2006−4472; 2009−5269; 2009−3413), the Medical Faculty, Umeå University, and the County Councils of Västerbotten and Norrbotten, Sweden. The Betula Study is supported by Grants 345−2003−3883 and 315−2004−6977 from the Swedish Research Council. Research nurses Annelie Nordin and Eva Lundberg are thankfully acknowledged for their help and expertise.
  • Funding Agencies|Swedish Research Council|2006-44722009-52692009-3413345-2003-3883315-2004-6977|Medical Faculty||Umea University||County Councils of Vasterbotten and Norrbotten, Sweden||
  • Background The hypothalamic-pituitary-adrenal (HPA) axis plays a central role in stress regulation, and leukocyte telomere length (TL) has been suggested to represent a cumulative measure of stress. Depression is intimately related with stress and frequently exhibits a dysregulated HPA axis. We aimed to study the relationships between TL and biological and psychological facets of stress in recurrent major depressive disorder and controls. Methods Leukocyte TL was measured in 91 subjects with recurrent major depressive disorder and 451 control subjects. Stress was assessed from both a biological perspective, by assessing HPA axis function with a weight-adjusted very-low-dose dexamethasone suppression test (DST), and a psychological perspective, with self-report questionnaires. Results TL was shorter among patients compared with control subjects (277 base pairs, p = .001). Overall, short TL was associated with a hypocortisolemic state (low post-DST cortisol and high percentage of cortisol reduction after the DST) among both patients and control subjects but more pronounced among patients. This state, which was overrepresented among patients, was characterized by high familial loading of affective disorders among patients (p = .001) and high C-reactive protein levels among control subjects (p = .040). TL was also inversely associated with stress measured with the Perceived Stress Questionnaire (rs = −.258, p = .003). Conclusions Short TL is associated with depression and hypocortisolism. Because hypocortisolism has been shown to develop from chronic stress exposure, our findings corroborate the concept of TL as a cumulative measure of stress and provide novel insights into the detrimental role of stress in depressive illness and the general population.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Maripuu, MartinUmeå universitet,Psykiatri,Umeå University(Swepub:umu)manmau98 (author)
  • Karlsson, ThomasLinköpings universitet,Institutionen för beteendevetenskap och lärande,Filosofiska fakulteten(Swepub:liu)thoka00 (author)
  • Nordfjäll, KatarinaUmeå universitet,Patologi,Umeå University (author)
  • Bergdahl, JanUmeå universitet,Institutionen för psykologi,Umeå University(Swepub:umu)jabe0001 (author)
  • Hultdin, JohanUmeå universitet,Klinisk kemi,Umeå University(Swepub:umu)johu0007 (author)
  • Del-Favero, JurgenUniversity of Antwerp, Antwerp, Belgium,VIB, Department of Molecular Genetics (author)
  • Roos, GöranUmeå universitet,Patologi,Umeå University(Swepub:umu)goro0001 (author)
  • Nilsson, Lars-GöranStockholms universitet,Psykologiska institutionen,Stockholm University, Department of Psychology(Swepub:su)lgn (author)
  • Adolfsson, RolfUmeå universitet,Psykiatri,Umeå University(Swepub:umu)road0001 (author)
  • Norrback, Karl-FredrikUmeå universitet,Psykiatri,Umeå University(Swepub:umu)kaknok96 (author)
  • Umeå universitetPsykiatri (creator_code:org_t)

Related titles

  • In:Biological PsychiatryNew York : Elsevier71:4, s. 294-3000006-32231873-2402

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view