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APOE ε4 is associat...
APOE ε4 is associated with longer telomeres, and longer telomeres among ε4 carriers predicts worse episodic memory
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- Wikgren, Mikael, 1981- (author)
- Umeå universitet,Psykiatri
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- Karlsson, Thomas (author)
- Linköpings universitet,Institutionen för beteendevetenskap och lärande,Filosofiska fakulteten
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- Nilbrink, Therese (author)
- Umeå universitet,Psykiatri
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- Nordfjäll, Katarina (author)
- Umeå universitet,Patologi
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- Hultdin, Johan (author)
- Umeå universitet,Klinisk kemi
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- Sleegers, Kristel (author)
- University of Antwerp, Antwerp, Belgium,VIB, Department of Molecular Genetics
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- Van Broeckhoven, Christine (author)
- University of Antwerp, Antwerp, Belgium,VIB, Department of Molecular Genetics
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- Nyberg, Lars (author)
- Umeå universitet,Diagnostisk radiologi,Fysiologi
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- Roos, Göran (author)
- Umeå universitet,Patologi
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- Nilsson, Lars-Göran (author)
- Stockholms universitet,Psykologiska institutionen,Stockholm University, Department of Psychology
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- Adolfsson, Rolf (author)
- Umeå universitet,Psykiatri
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- Norrback, Karl-Fredrik (author)
- Umeå universitet,Psykiatri
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(creator_code:org_t)
- Elsevier, 2012
- 2012
- English.
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In: Neurobiology of Aging. - : Elsevier. - 0197-4580 .- 1558-1497. ; 33:2, s. 335-344
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https://doi.org/10.1...
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Abstract
Subject headings
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- Both leukocyte telomere length and the apolipoprotein ε4 allele have been associated with mortality, cardiovascular disease, cognition, and dementia. The authors investigated whether leukocyte telomere length was associated with APOE genotype or cognitive abilities in the context of APOE genotype. The setting for this cross-sectional study was 427 nondemented individuals aged 41–81 yr. The authors found that ε4 carriers overall exhibited significantly longer telomeres compared with non-carriers (difference of 268 bp, p = 0.001). This difference was greatest at the lower limit of the age span and nonsignificant at the upper limit, which translated into a significantly higher telomere attrition rate (p = 0.049) among ε4 carriers (37 bp/years) compared with non-carriers (21 bp/year). Further, longer telomeres among ε4 carriers significantly predicted worse performance on episodic memory tasks. No significant associations were found on tasks tapping semantic and visuospatial ability, or among ε3/ε3 carriers. In conclusion, APOE ε4 carriers had longer telomeres compared with non-carriers, but higher rate of attrition. Among them, longer telomeres predicted worse performance on episodic memory tasks. These observations suggest that the ε4 allele is associated with abnormal cell turnover of functional and possibly clinical significance.
Subject headings
- SAMHÄLLSVETENSKAP -- Psykologi -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- APOE
- cognition
- telomere length
- Psychology
- Psykologi
- psykologi
- Psychology
- MEDICINE
- SOCIAL SCIENCES
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Wikgren, Mikael, ...
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Karlsson, Thomas
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Nilbrink, Theres ...
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Nordfjäll, Katar ...
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Hultdin, Johan
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Sleegers, Kriste ...
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show more...
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Van Broeckhoven, ...
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Nyberg, Lars
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Roos, Göran
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Nilsson, Lars-Gö ...
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Adolfsson, Rolf
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Norrback, Karl-F ...
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show less...
- About the subject
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
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and Psychology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Neurobiology of ...
- By the university
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Stockholm University
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Umeå University
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Linköping University