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Prostate alpha/beta...
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Dasu, AlexandruLinköpings universitet,Östergötlands Läns Landsting,Radiofysikavdelningen US,Hälsouniversitetet,Avdelningen för radiologiska vetenskaper
(författare)
Prostate alpha/beta revisited - an analysis of clinical results from 14168 patients
- Artikel/kapitelEngelska2012
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:su-79116
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-79116URI
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https://doi.org/10.3109/0284186X.2012.719635DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-79613URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:125414341URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:for swepub-publicationtype
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Purpose: To determine the dose response parameters and the fractionation sensitivity of prostate tumours from clinical results of patients treated with external beam radiotherapy.Material and methods: The study was based on 5-year biochemical results from 14168 patients treated with external beam radiotherapy. Treatment data from 11330 patients treated with conventional fractionation have been corrected for overall treatment time and fitted with a logit equation. The results have been used to determine the optimum α/β values that minimise differences in predictions from 2838 patients treated with hypofractionated schedules.Results: Conventional fractionation data yielded logit dose response parameters for all risk groups and for all definitions of biochemical failures. The analysis of hypofractionation data led to very low α/β values (1-1.7 Gy) in all mentioned cases. Neglecting the correction for overall treatment time has little impact on the derivation of α/β values for prostate cancers.Conclusions: These results indicate that the high fractionation sensitivity is an intrinsic property of prostate carcinomas and they support the use of hypofractionation to increase the therapeutic gain for these tumours.
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Toma-Dasu, IulianaStockholms universitet,Fysikum,Karolinska Institutet, Sweden,Stockholm University and Karolinska Institutet(Swepub:su)iuda0736
(författare)
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Östergötlands Läns LandstingRadiofysikavdelningen US
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Acta Oncologica51:8, s. 963-9740284-186X1651-226X
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