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Brain Structure in ...
Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa : A Coordinated Analysis by the ENIGMA Eating Disorders Working Group
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- Walton, Esther (författare)
- Univ Bath, Dept Psychol, Bath, Avon, England.
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- Bernardoni, Fabio (författare)
- Tech Univ Dresden, Div Psychol & Social Med & Dev Neurosci, Fac Med, Dept Child & Adolescent Psychiat, Dresden, Germany.
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- Batury, Victoria-Luise (författare)
- Tech Univ Dresden, Div Psychol & Social Med & Dev Neurosci, Fac Med, Dept Child & Adolescent Psychiat, Dresden, Germany.
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visa fler...
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- Bahnsen, Klaas (författare)
- Tech Univ Dresden, Div Psychol & Social Med & Dev Neurosci, Fac Med, Dept Child & Adolescent Psychiat, Dresden, Germany.
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- Lariviere, Sara (författare)
- McGill Univ, Montreal Neurol Inst & Hosp, McConnell Brain Imaging Ctr, Multimodal Imaging & Connectome Anal Lab, Montreal, PQ, Canada.
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- Abbate-Daga, Giovanni (författare)
- Univ Turin, Eating Disorders Ctr Treatment & Res, Turin, Italy.
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- Andres-Perpina, Susana (författare)
- Univ Barcelona, Hosp Clin Univ, Ctr Invest Biomed Red Salud Mental, Inst Clin Neurociencies, Barcelona, Spain.
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- Bang, Lasse (författare)
- Norwegian Inst Publ Hlth, Oslo, Norway.;Oslo Univ Hosp, Reg Dept Eating Disorders, Div Mental Hlth & Addict, Oslo, Norway.
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- Bischoff-Grethe, Amanda (författare)
- Univ Calif San Diego, Dept Psychiat, La Jolla, CA USA.;Univ Calif San Diego, Eating Disorders Ctr Treatment & Res, La Jolla, CA 92093 USA.
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- Brooks, Samantha (författare)
- Uppsala universitet,Institutionen för neurovetenskap,Liverpool John Moores Univ, Fac Hlth Sci, Sch Psychol, Liverpool, Merseyside, England.
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- Campbell, Iain C. (författare)
- Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England.;Kings Coll London, Dept Psychol Med, Eating Disorders Unit, London, England.
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- Cascino, Giammarco (författare)
- Univ Salerno, Dept Med, Sect Neurosci, Scuola Med Salernitana, Salerno, Italy.
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- Castro-Fornieles, Josefina (författare)
- Univ Barcelona, Hosp Clin Univ, Ctr Invest Biomed Red Salud Mental, Inst Clin Neurociencies, Barcelona, Spain.
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- Collantoni, Enrico (författare)
- Univ Padua, Dept Neurosci, Padua, Italy.
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- D'Agata, Federico (författare)
- Univ Turin, Dept Neurosci, Turin, Italy.
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- Dahmen, Brigitte (författare)
- Univ Hosp Rhein Westfalische TH Aachen, Dept Child & Adolescent Psychiat, Psychosomat & Psychotherapy, Aachen, Germany.
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- Danner, Unna N. (författare)
- Altrecht Mental Hlth Inst, Altrecht Eating Disorders Rintveld, Zeist, Netherlands.;Univ Utrecht, Fac Social Sci, Utrecht, Netherlands.
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- Favaro, Angela (författare)
- Univ Padua, Dept Neurosci, Padua, Italy.;Univ Padua, Padova Neurosci Ctr, Padua, Italy.
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- Feusner, Jamie D. (författare)
- Univ Toronto, Ctr Addict & Mental Hlth, Toronto, ON, Canada.;Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
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- Frank, Guido K. W. (författare)
- Univ Calif San Diego, Dept Psychiat, La Jolla, CA USA.;Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
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- Friederich, Hans-Christoph (författare)
- Univ Hosp Heidelberg, Ctr Psychosocial Med, Dept Gen Internal Med & Psychosomat, Heidelberg, Germany.
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- Graner, John L. (författare)
- Duke Univ, Ctr Cognit Neurosci, Durham, NC USA.
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- Herpertz-Dahlmann, Beate (författare)
- Univ Hosp Rhein Westfalische TH Aachen, Dept Child & Adolescent Psychiat, Psychosomat & Psychotherapy, Aachen, Germany.
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- Hess, Andreas (författare)
- Univ Erlangen Nurnberg, Inst Pharmacol & Toxicol, Erlangen, Germany.
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- Horndasch, Stefanie (författare)
- Univ Clin Erlangen, Dept Child & Adolescent Psychiat, Erlangen, Germany.
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- Kaplan, Allan S. (författare)
- Univ Toronto, Ctr Addict & Mental Hlth, Toronto, ON, Canada.
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- Kaufmann, Lisa-Katrin (författare)
- Univ Zurich, Univ Hosp Zurich, Dept Consultat Liaison Psychiat & Psychosomat, Zurich, Switzerland.;Univ Zurich, Dept Psychol, Div Neuropsychol, Zurich, Switzerland.
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- Kaye, Walter H. (författare)
- Univ Calif San Diego, Dept Psychiat, La Jolla, CA USA.;Univ Calif San Diego, Eating Disorders Ctr Treatment & Res, La Jolla, CA 92093 USA.
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- Khalsa, Sahib S. (författare)
- Univ Tulsa, Laureate Inst Brain Res, Tulsa, OK USA.;Univ Tulsa, Oxley Coll Hlth Sci, Tulsa, OK USA.
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- LaBar, Kevin S. (författare)
- Duke Univ, Ctr Cognit Neurosci, Durham, NC USA.
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- Lavagnino, Luca (författare)
- Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, McGovern Med Sch, Houston, TX 77030 USA.
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- Lazaro, Luisa (författare)
- Univ Barcelona, Hosp Clin Univ, Ctr Invest Biomed Red Salud Mental, Inst Clin Neurociencies, Barcelona, Spain.
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- Manara, Renzo (författare)
- Univ Padua, Dept Neurosci, Padua, Italy.
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- Miles, Amy E. (författare)
- Univ Toronto, Ctr Addict & Mental Hlth, Toronto, ON, Canada.
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- Milos, Gabriella F. (författare)
- Univ Zurich, Univ Hosp Zurich, Dept Consultat Liaison Psychiat & Psychosomat, Zurich, Switzerland.
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- Monteleone, Alessio Maria (författare)
- Univ Campania L Vanvitelli, Dept Psychiat, Naples, Italy.
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- Monteleone, Palmiero (författare)
- Univ Salerno, Dept Med, Sect Neurosci, Scuola Med Salernitana, Salerno, Italy.
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- Mwangi, Benson (författare)
- Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, McGovern Med Sch, Houston, TX 77030 USA.
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- O'Daly, Owen (författare)
- Kings Coll London, Ctr Neuroimaging Studies, London, England.;Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England.
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- Pariente, Jose (författare)
- Inst Invest Biomed August Pi I Sunyer, Magnet Resonance Image Core Facil, Barcelona, Spain.
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- Roesch, Julie (författare)
- Univ Clin Erlangen, Dept Neuroradiol, Erlangen, Germany.
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- Schmidt, Ulrike H. (författare)
- Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England.;Kings Coll London, Dept Psychol Med, Eating Disorders Unit, London, England.
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- Seitz, Jochen (författare)
- Univ Hosp Rhein Westfalische TH Aachen, Dept Child & Adolescent Psychiat, Psychosomat & Psychotherapy, Aachen, Germany.
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- Shott, Megan E. (författare)
- Univ Calif San Diego, Dept Psychiat, La Jolla, CA USA.;Univ Calif San Diego, Eating Disorders Ctr Treatment & Res, La Jolla, CA 92093 USA.
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- Simon, Joe J. (författare)
- Univ Hosp Heidelberg, Ctr Psychosocial Med, Dept Gen Internal Med & Psychosomat, Heidelberg, Germany.
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- Smeets, Paul A. M. (författare)
- Univ Utrecht, UMC Utrecht Brain Ctr, Utrecht, Netherlands.;Wageningen Univ, Div Human Nutr & Hlth, Wageningen, Netherlands.
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- Tamnes, Christian K. (författare)
- Univ Oslo, Norwegian Ctr Mental Disorders Res, Inst Clin Med, Oslo, Norway.;Univ Oslo, PROMENTA Res Ctr, Dept Psychol, Oslo, Norway.;Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.
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- Tenconi, Elena (författare)
- Univ Padua, Dept Neurosci, Padua, Italy.;Univ Padua, Padova Neurosci Ctr, Padua, Italy.
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- Thomopoulos, Sophia, I (författare)
- Univ Southern Calif, Imaging Genet Ctr, Keck Sch Med, Mark & Mary Stevens Neuroimaging & Informat Inst, Marina Del Rey, CA USA.
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- van Elburg, Annemarie A. (författare)
- Altrecht Mental Hlth Inst, Altrecht Eating Disorders Rintveld, Zeist, Netherlands.;Univ Utrecht, Fac Social Sci, Utrecht, Netherlands.
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- Voineskos, Aristotle N. (författare)
- Univ Toronto, Campbell Family Mental Hlth Res Inst, Toronto, ON, Canada.;Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
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- von Polier, Georg G. (författare)
- Univ Hosp Rhein Westfalische TH Aachen, Dept Child & Adolescent Psychiat, Psychosomat & Psychotherapy, Aachen, Germany.;Forschungszentrum Julich, Inst Neurosci & Med Brain & Behav, Julich, Germany.;Goethe Univ, Univ Hosp Frankfurt, Dept Child & Adolescent Psychiat, Frankfurt, Germany.
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- Wierenga, Christina E. (författare)
- Univ Calif San Diego, Dept Psychiat, La Jolla, CA USA.;Univ Calif San Diego, Eating Disorders Ctr Treatment & Res, La Jolla, CA 92093 USA.
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- Zucker, Nancy L. (författare)
- Duke Univ Med Ctr, Dept Psychiat & Behav Sci, Durham, NC USA.
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- Jahanshad, Neda (författare)
- Univ Southern Calif, Imaging Genet Ctr, Keck Sch Med, Mark & Mary Stevens Neuroimaging & Informat Inst, Marina Del Rey, CA USA.
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- King, Joseph A. (författare)
- Tech Univ Dresden, Div Psychol & Social Med & Dev Neurosci, Fac Med, Dept Child & Adolescent Psychiat, Dresden, Germany.
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- Thompson, Paul M. (författare)
- Univ Southern Calif, Imaging Genet Ctr, Keck Sch Med, Mark & Mary Stevens Neuroimaging & Informat Inst, Marina Del Rey, CA USA.
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- Berner, Laura A. (författare)
- Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
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- Ehrlich, Stefan (författare)
- Tech Univ Dresden, Div Psychol & Social Med & Dev Neurosci, Fac Med, Dept Child & Adolescent Psychiat, Dresden, Germany.;Tech Univ Dresden, Eating Disorders Res & Treatment Ctr, Dept Child & Adolescent Psychiat, Fac Med, Dresden, Germany.
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Univ Bath, Dept Psychol, Bath, Avon, England Tech Univ Dresden, Div Psychol & Social Med & Dev Neurosci, Fac Med, Dept Child & Adolescent Psychiat, Dresden, Germany. (creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Biological Psychiatry. - : Elsevier. - 0006-3223 .- 1873-2402. ; 92:9, s. 730-738
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The pattern of structural brain abnormalities in anorexia nervosa (AN) is still not well understood. While several studies report substantial deficits in gray matter volume and cortical thickness in acutely underweight patients, others find no differences, or even increases in patients compared with healthy control subjects. Recent weight regain before scanning may explain some of this heterogeneity. To clarify the extent, magnitude, and de-pendencies of gray matter changes in AN, we conducted a prospective, coordinated meta-analysis of multicenter neuroimaging data.METHODS: We analyzed T1-weighted structural magnetic resonance imaging scans assessed with standardized methods from 685 female patients with AN and 963 female healthy control subjects across 22 sites worldwide. In addition to a case-control comparison, we conducted a 3-group analysis comparing healthy control subjects with acutely underweight AN patients (n = 466) and partially weight-restored patients in treatment (n = 251).RESULTS: In AN, reductions in cortical thickness, subcortical volumes, and, to a lesser extent, cortical surface area were sizable (Cohen's d up to 0.95), widespread, and colocalized with hub regions. Highlighting the effects of un-dernutrition, these deficits were associated with lower body mass index in the AN sample and were less pronounced in partially weight-restored patients.CONCLUSIONS: The effect sizes observed for cortical thickness deficits in acute AN are the largest of any psychiatric disorder investigated in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium to date. These results confirm the importance of considering weight loss and renutrition in biomedical research on AN and underscore the importance of treatment engagement to prevent potentially long-lasting structural brain changes in this population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
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Walton, Esther
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Bernardoni, Fabi ...
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Batury, Victoria ...
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Bahnsen, Klaas
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Lariviere, Sara
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Abbate-Daga, Gio ...
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visa fler...
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Andres-Perpina, ...
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Bang, Lasse
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Bischoff-Grethe, ...
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Brooks, Samantha
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Campbell, Iain C ...
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Cascino, Giammar ...
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Castro-Fornieles ...
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Collantoni, Enri ...
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D'Agata, Federic ...
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Dahmen, Brigitte
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Danner, Unna N.
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Favaro, Angela
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Feusner, Jamie D ...
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Frank, Guido K. ...
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Friederich, Hans ...
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Graner, John L.
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Herpertz-Dahlman ...
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Hess, Andreas
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Horndasch, Stefa ...
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Kaplan, Allan S.
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Kaufmann, Lisa-K ...
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Kaye, Walter H.
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Khalsa, Sahib S.
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LaBar, Kevin S.
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Lavagnino, Luca
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Lazaro, Luisa
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Manara, Renzo
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Miles, Amy E.
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Milos, Gabriella ...
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Monteleone, Ales ...
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Monteleone, Palm ...
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Mwangi, Benson
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O'Daly, Owen
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Pariente, Jose
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Roesch, Julie
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Schmidt, Ulrike ...
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Seitz, Jochen
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Shott, Megan E.
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Simon, Joe J.
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Smeets, Paul A. ...
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Tamnes, Christia ...
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Tenconi, Elena
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Thomopoulos, Sop ...
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van Elburg, Anne ...
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Voineskos, Arist ...
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von Polier, Geor ...
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Wierenga, Christ ...
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Zucker, Nancy L.
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Jahanshad, Neda
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King, Joseph A.
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Thompson, Paul M ...
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Berner, Laura A.
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Ehrlich, Stefan
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