The role of natural killer cells and inflammatory mediators in preeclamptic pregnancies

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Bachmayer, Nora,0061-Stockholms universitet,Wenner-Grens institut (författare)

The role of natural killer cells and inflammatory mediators in preeclamptic pregnancies

BokEngelska2008

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Stockholm :Wenner-Grens institut för experimentell biologi,2008
94 s.
electronicrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:su-8220
ISBN:9789171557421
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8220URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:vet swepub-contenttype
Ämneskategori:dok swepub-publicationtype

Anmärkningar

The maternal immune system must be able to adjust during pregnancy and accept the foetus that expresses paternal antigens. These changes are found both in placenta and circulation, including a mild inflammatory response. NK cells are abundant during the early part of pregnancy in placenta and are thought to be important for placental development. During preeclampsia the placenta is poorly developed, together with an escalated pro-inflammatory profile noticed in both placenta and circulation. We wanted to study NK cells in placenta and circulation from preeclamptic cases as well as levels of cytokines. HMGB1, an alarmin involved in inflammation, was also measured in preeclamptic placentae.When studying preeclamptic placentae in third trimester we found higher numbers of NK cells as well as a higher expression of CD94+ NK cells. We also found slightly elevated levels of HMGB1 together with significantly lower expression of IL-12 in preeclamptic placentae. Further, the NK cell activating cytokines IL-12/IL-23p40 and IL-15 in sera from preeclamptic women were increased compared to healthy pregnancies. The elevated levels of NK cell activating IL-12/IL-23p40 and IL-15 found in preeclamptic sera, made us investigate the circulating NK cells in preeclampsia. However, no differences were seen between healthy and preeclamptic pregnancies.The main immunological alterations in third trimester preeclamptic pregnancies with regard to NK cells were found in placenta. Altered maternal cytokine levels in placenta could influence decidual NK cells in preeclampsia, noticed by their higher numbers and altered receptor expression. If these alterations also exist during early pregnancy it could result in a poorly developed and dysfunctional placenta.

Ämnesord och genrebeteckningar

NATURVETENSKAP Biologi Immunologi hsv//swe
NATURAL SCIENCES Biological Sciences Immunology hsv//eng
preeclampsia
NK cells
Immunology
Immunologi
immunologi
Immunology

Biuppslag (personer, institutioner, konferenser, titlar ...)

Sverremark-Ekström, Eva,DocentStockholms universitet,Wenner-Grens institut (preses)
Bremme, Katarina (preses)
Mincheva-Nilsson, Lucia,DocentInstitutionen för klinisk mikrobiologi, Umeå universitet (opponent)
Stockholms universitetWenner-Grens institut (creator_code:org_t)

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Av författaren/redakt...: Bachmayer, Nora, ...; Sverremark-Ekstr ...; Bremme, Katarina; Mincheva-Nilsson ...

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NATURVETENSKAP: NATURVETENSKAP; och Biologi; och Immunologi

Av lärosätet: Stockholms universitet

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