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Influence of liver-...
Influence of liver-X-receptor on tissue cholesterol, coenzyme Q and dolichol content
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- Bentinger, Magnus (författare)
- Stockholms universitet,Institutionen för biokemi och biofysik,Karolinska Institutet, Sweden
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- Tekle, Michael (författare)
- Stockholms universitet,Institutionen för biokemi och biofysik,Karolinska Institutet, Sweden
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- Dallner, Gustav (författare)
- Stockholms universitet,Institutionen för biokemi och biofysik,Karolinska Institutet, Sweden
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- Brismar, Kerstin (författare)
- Karolinska Institutet
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- Gustafsson, Jan-Åke (författare)
- Karolinska Institutet
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- Steffensen, Knut R. (författare)
- Karolinska Institutet
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- Sergiu-Bogdan, Catrina (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2012-06-14
- 2012
- Engelska.
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Ingår i: Molecular membrane biology. - : Informa UK Limited. - 0968-7688 .- 1464-5203. ; 29:7, s. 299-308
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The organ content of the mevalonate pathway lipids was investigated in liver-X-receptor (LXR) alpha, beta and double knockout mice. An extensive or moderate increase of total cholesterol in the double KO mice was found in all organs elicited by the increase of the esterified form. In LXR alpha and double KO mice, coenzyme Q (CoQ) was decreased in liver and increased in spleen, thymus and lung, while dolichol was increased in all organs investigated. This effect was confirmed using LXR-agonist GW 3965. Analysis of CoQ distribution in organelles showed that the modifications are present in all cellular compartments and that the increase of the lipid in mitochondria was the result of a net increase of CoQ without changing the number of mitochondria. It appears that LXR influences not only cellular cholesterol homeostasis but also the metabolism of CoQ and dolichol, in an indirect manner.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Liver-X-receptor
- coenzyme Q
- cholesterol
- dolichol
- membrane modification
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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