Midlife healthy-diet index and late-life dementia and Alzheimer's disease

Sökning: L773:1664 5464 > Midlife healthy-die...

Eskelinen, Marjo HDepartment of Neurology, University of Eastern Finland, Kuopio (författare)

AIM: To study long-term effects of dietary patterns on dementia and Alzheimer's disease (AD). METHODS: Of 525 subjects randomly selected from population-based cohorts surveyed at midlife, a total of 385 (73%) subjects were re-examined 14 years later in the CAIDE study. A healthy-diet index (range 0-17) was constructed including both healthy and unhealthy dietary components. RESULTS: Persons with a healthy diet (healthy-diet index >8 points) had a decreased risk of dementia (OR 0.12, 95% CI 0.02-0.85) and AD (OR 0.08, 95% CI 0.01-0.89) compared with persons with an unhealthy diet (0-8 points), adjusting for several possible confounders. CONCLUSIONS: Healthy diet at midlife is associated with a decreased risk of dementia/AD in late life. These findings highlight the importance of dietary patterns and may make more effective measures for dementia/AD prevention or postponement possible.

Ngandu, TiiaKarolinska Institutet (författare)
Tuomilehto, JaakkoDepartment of Health Promotion and Chronic Disease Prevention, National Institute for Health and Welfare (författare)
Soininen, HilkkaDepartment of Neurology, University of Eastern Finland, Kuopio (författare)
Kivipelto, MiiaStockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (författare)
Karolinska InstitutetDepartment of Neurology, University of Eastern Finland, Kuopio (creator_code:org_t)

Ingår i:Dementia and Geriatric Cognitive Disorders ExtraBasel : S. Karger1:1, s. 103-1121664-5464

Av författaren/redakt...: Eskelinen, Marjo ...; Ngandu, Tiia; Tuomilehto, Jaak ...; Soininen, Hilkka; Kivipelto, Miia

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