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  • Gil-Bea, Francisco JKarolinska Institutet (author)

Insulin levels are decreased in the cerebrospinal fluid of women with prodomal Alzheimer's disease

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • Amsterdam; Washington :IOS Press,2010
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-85027
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-85027URI
  • https://doi.org/10.3233/JAD-2010-100795DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:121942565URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Previous studies have failed to reach consensus on insulin levels in cerebrospinal fluid of Alzheimer's disease (AD) patients and on its relation to pathological features. We performed a new analysis in patients at different stages of AD, and investigated the relationship of insulin levels with biochemical disease markers and with cognitive score. We included 99 patients from our Memory Clinic (Karolinska University Hospital, Sweden), including: 27 patients with mild AD, 13 that progressed from mild cognitive impairment (MCI) to AD in two years time, 26 with MCI stable after two years, and 33 with subjective cognitive impairment. Insulin was significantly decreased in the cerebrospinal fluid of both women and men with mild AD. Insulin deficits were seen in women belonging to both MCI groups, suggesting that this occurs earlier than in men. Insulin was positively associated with amyloid-β 1-42 (Aβ1-42) levels and cognitive score. Furthermore, total-tau/(Aβ1-42*insulin) ratio showed strikingly better sensitivity and specificity than the total-tau/Aβ1-42 ratio for early AD diagnosis in women.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Solas, Maite (author)
  • Solomon, AlinaKarolinska Institutet (author)
  • Mugueta, Carmen (author)
  • Winblad, BengtKarolinska Institutet (author)
  • Kivipelto, MiiaKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (author)
  • Ramirez, Maria J (author)
  • Cedazo-Mínguez, AngelKarolinska Institutet (author)
  • Karolinska InstitutetCentrum för forskning om äldre och åldrande (ARC), (tills m KI) (creator_code:org_t)

Related titles

  • In:Journal of Alzheimer's DiseaseAmsterdam; Washington : IOS Press22:2, s. 405-4131387-28771875-8908

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