SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Lemnge Martha)
 

Sökning: WFRF:(Lemnge Martha) > (2012) > Biomarkers of Plasm...

  • Boström, Stéphanie,1985-Stockholms universitet,Wenner-Grens institut (författare)

Biomarkers of Plasmodium falciparum infection during pregnancy in women living in Northeastern Tanzania

  • Artikel/kapitelEngelska2012

Förlag, utgivningsår, omfång ...

  • 2012-11-14
  • Public Library of Science (PLoS),2012
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:su-86295
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-86295URI
  • https://doi.org/10.1371/journal.pone.0048763DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • In pregnant women, Plasmodium falciparum infections are an important cause of maternal morbidity as well as fetal and neonatal mortality. Erythrocytes infected by these malaria-causing parasites accumulate through adhesive interactions in placental intervillous spaces, thus evading detection in peripheral blood smears. Sequestered infected erythrocytes induce inflammation, offering the possibility of detecting inflammatory mediators in peripheral blood that could act as biomarkers of placental infection. In a longitudinal, prospective study in Tanzania, we quantified a range of different cytokines, chemokines and angiogenic factors in peripheral plasma samples, taken on multiple sequential occasions during pregnancy up to and including delivery, from P. falciparum-infected women and matched uninfected controls. The results show that during healthy, uninfected pregnancies the levels of most of the panel of molecules we measured were largely unchanged except at delivery. In women with P. falciparum, however, both comparative and longitudinal assessments consistently showed that the levels of IL-10 and IP-10 increased significantly whilst that of RANTES decreased significantly, regardless of gestational age at the time the infection was detected. ROC curve analysis indicated that a combination of increased IL-10 and IP-10 levels and decreased RANTES levels might be predictive of P. falciparum infections. In conclusion, our data suggest that host biomarkers in peripheral blood may represent useful diagnostic markers of P. falciparum infection during pregnancy, but placental histology results would need to be included to verify these findings.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ibitokou, Samad (författare)
  • Oesterholt, Mayke (författare)
  • Schmiegelow, Christentze (författare)
  • Persson, Jan-OlovStockholms universitet,Matematiska institutionen(Swepub:su)japer (författare)
  • Minja, Daniel (författare)
  • Lusingu, John (författare)
  • Lemnge, Martha (författare)
  • Fievet, Nadine (författare)
  • Deloron, Philippe (författare)
  • Luty, Adrian J. F. (författare)
  • Troye-Blomberg, MaritaStockholms universitet,Wenner-Grens institut(Swepub:su)marita (författare)
  • Stockholms universitetWenner-Grens institut (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:PLOS ONE: Public Library of Science (PLoS)7:11, s. e48763-1932-6203

Internetlänk

Hitta via bibliotek

  • PLOS ONE (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy