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Factors associated ...
Factors associated with health-related quality of life (HRQoL) deterioration in glioma patients during the progression-free survival period
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- Coomans, Marijke (författare)
- Leiden Univ, Netherlands
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- Dirven, Linda (författare)
- Leiden Univ, Netherlands; Haaglanden Med Ctr, Netherlands
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- Aaronson, Neil (författare)
- Netherlands Canc Inst, Netherlands
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- Baumert, Brigitta G. (författare)
- Kantonsspital Graubunden, Switzerland; Maastricht Univ, Netherlands; Maastricht Univ, Netherlands
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- van den Bent, Martin (författare)
- Erasmus MC Canc Inst, Netherlands
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- Bottomley, Andrew (författare)
- European Org Res Treatment Canc, Belgium
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- Brandes, Alba A. (författare)
- Azienda USL IRCCS Inst Neurol Sci, Italy
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- Chinot, Olivier (författare)
- Aix Marseille Univ, France
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- Coens, Corneel (författare)
- European Org Res Treatment Canc, Belgium
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- Gorlia, Thierry (författare)
- European Org Res & Treatment Canc Headquarters, Belgium
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- Herrlinger, Ulrich (författare)
- Univ Bonn, Germany
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- Keime-Guibert, Florence (författare)
- Grp Hop Pitie Salpetriere, France
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- Malmström, Annika (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Närvårdskliniken
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- Martinelli, Francesca (författare)
- European Org Res Treatment Canc, Belgium
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- Stupp, Roger (författare)
- Northwestern Univ, IL 60611 USA
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- Talacchi, Andrea (författare)
- Azienda Osped San Giovanni Addolorata, Italy
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- Weller, Michael (författare)
- Univ Hosp, Switzerland; Univ Zurich, Switzerland
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- Wick, Wolfgang (författare)
- Univ Hosp Heidelberg, Germany; Univ Hosp Heidelberg, Germany; German Canc Res Ctr, Germany
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- Reijneveld, Jaap C. (författare)
- Univ Amsterdam, Netherlands; Univ Amsterdam, Netherlands
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- Taphoorn, Martin J. B. (författare)
- Leiden Univ, Netherlands; Haaglanden Med Ctr, Netherlands
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(creator_code:org_t)
- 2022-04-11
- 2022
- Engelska.
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Ingår i: Neuro-Oncology. - : Oxford University Press. - 1522-8517 .- 1523-5866. ; 24:12, s. 2159-2169
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Maintenance of functioning and well-being during the progression-free survival (PFS) period is important for glioma patients. This study aimed to determine whether health-related quality of life (HRQoL) can be maintained during progression-free time, and factors associated with HRQoL deterioration in this period. Methods We included longitudinal HRQoL data from previously published clinical trials in glioma. The percentage of patients with stable HRQoL until progression was determined per scale and at the individual patient level (i.e. considering all scales simultaneously). We assessed time to a clinically relevant deterioration in HRQoL, expressed in deterioration-free survival and time-to-deterioration (the first including progression as an event). We also determined the association between sociodemographic and clinical factors and HRQoL deterioration in the progression-free period. Results Five thousand five hundred and thirty-nine patients with at least baseline HRQoL scores had a median time from randomization to progression of 7.6 months. Between 9-29% of the patients deteriorated before disease progression on the evaluated HRQoL scales. When considering all scales simultaneously, 47% of patients deteriorated on >= 1 scale. Median deterioration-free survival period ranged between 3.8-5.4 months, and median time-to-deterioration between 8.2-11.9 months. For most scales, only poor performance status was independently associated with clinically relevant HRQoL deterioration in the progression-free period. Conclusions HRQoL was maintained in only 53% of patients in their progression-free period, and treatment was not independently associated with this deterioration in HRQoL. Routine monitoring of the patients functioning and well-being during the entire disease course is therefore important, so that interventions can be initiated when problems are signaled.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- brain tumor; deterioration-free-survival; progressive disease; time-to-deterioration
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Coomans, Marijke
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Dirven, Linda
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Aaronson, Neil
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Baumert, Brigitt ...
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van den Bent, Ma ...
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Bottomley, Andre ...
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visa fler...
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Brandes, Alba A.
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Chinot, Olivier
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Coens, Corneel
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Gorlia, Thierry
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Herrlinger, Ulri ...
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Keime-Guibert, F ...
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Malmström, Annik ...
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Martinelli, Fran ...
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Stupp, Roger
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Talacchi, Andrea
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Weller, Michael
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Wick, Wolfgang
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Reijneveld, Jaap ...
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Taphoorn, Martin ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Neuro-Oncology
- Av lärosätet
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Linköpings universitet