Gestational age-related changes in the peripheral blood cell composition of sub-Saharan African women

AuthorCount:9;
Gestational age-related changes in the cellular composition of peripheral blood have not been described in sub-Saharan African settings. We conducted longitudinal cohort studies in Beninese and Tanzanian mothers with quantification of peripheral blood mononuclear cell-types ex vivo using flow cytometry. Between the second trimester and delivery the frequency of CD4(+) T cells declined significantly, contrasting with a non-significant increase in CD8(+) T cells, but no changes in T-regulatory, NK or NKT cell frequencies. Antigen-presenting cell profiles were also unaltered, although non-significant trends were evident. These changes resemble in some respects those reported during pregnancies in developed countries, but differ in others.

Brutus, Laurent (author)
Vianou, Bertin (author)
Oesterholt, Mayke (author)
Massougbodji, Achille (author)
Deloron, Philippe (author)
Troye-Blomberg, MaritaStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut(Swepub:su)marita (author)
Fievet, Nadine (author)
Luty, Adrian J. F. (author)
Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut (creator_code:org_t)

In:Journal of Reproductive Immunology: Elsevier BV98:1-2, s. 21-280165-03781872-7603

By the author/editor: Ibitokou, Samad; Brutus, Laurent; Vianou, Bertin; Oesterholt, Mayk ...; Massougbodji, Ac ...; Deloron, Philipp ...; show more...; Troye-Blomberg, ...; Fievet, Nadine; Luty, Adrian J. ...; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Immunology

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