Relationship of Subjective Cognitive Impairment and Cognitive Impairment No Dementia to Chronic Disease and Multimorbidity in a Nation-Wide Twin Study

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Caracciolo, BarbaraKarolinska Institutet,Stockholms universitet,Stressforskningsinstitutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (författare)

Relationship of Subjective Cognitive Impairment and Cognitive Impairment No Dementia to Chronic Disease and Multimorbidity in a Nation-Wide Twin Study

Artikel/kapitelEngelska2013

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2013
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LIBRIS-ID:oai:DiVA.org:su-92148
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-92148URI
https://doi.org/10.3233/JAD-122050DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:127013652URI

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Språk:engelska
Sammanfattning på:engelska

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AuthorCount:6;Sevearl other funders
We investigated the relation of subjective cognitive impairment (SCI) and cognitive impairment no dementia (CIND) to common chronic diseases of the elderly and multimorbidity, and assessed the contribution of genetic background and shared familial environment to these associations. Subjects were 11,379 dementia-free twin individuals aged >= 65 from the Swedish Twin Registry. SCI was defined as subjective complaint of cognitive change without objective cognitive impairment and CIND was defined according to current criteria. In unmatched, fully-adjusted regression models, mental, musculoskeletal, respiratory, and urological diseases were all significantly associated with increased odds ratios (ORs) of SCI and CIND. Circulatory and gastrointestinal diseases were related to SCI only, while endocrine diseases were associated with CIND. The adjusted ORs of multimorbidity were 2.1 [95% confidence intervals (95% CI): 1.8-2.3] for SCI and 1.5 for CIND (95% CI: 1.3-1.8). A dose-dependent relationship was observed between number of chronic diseases and ORs for SCI but not for CIND. In co-twin control analyses, the chronic diseases-SCI association was largely unchanged. On the other hand, the chronic diseases-CIND association was no longer statistically significant, except for cancer, where an increased OR was observed. In conclusion, chronic morbidity is associated with both SCI and CIND but disease profiles do not always overlap between the two cognitive syndromes. The association is stronger when diseases co-occur, especially for SCI. Genetic and early-life environmental factors may partially explain the association of CIND but not that of SCI with chronic diseases.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Chronic diseases
chronic morbidity
cognitive impairment
co-morbidity
cross-sectional
population-based
subjective cognitive complaints
twin-study

Biuppslag (personer, institutioner, konferenser, titlar ...)

Gatz, Margaret (författare)
Xu, WeiliKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (författare)
Marengoni, AlessandraKarolinska Institutet (författare)
Pedersen, Nancy L.Karolinska Institutet (författare)
Fratiglioni, LauraKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (författare)
Stockholms universitetStressforskningsinstitutet (creator_code:org_t)

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Ingår i:Journal of Alzheimer's Disease36:2, s. 275-2841387-28771875-8908

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Av författaren/redakt...: Caracciolo, Barb ...; Gatz, Margaret; Xu, Weili; Marengoni, Aless ...; Pedersen, Nancy ...; Fratiglioni, Lau ...

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Av lärosätet: Stockholms universitet; Karolinska Institutet

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