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Systemic Th1/Th2 cy...
Systemic Th1/Th2 cytokine responses to paternal and vaccination antigens in preeclampsia: no differences compared with normal pregnancy
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- Jonsson, Yvonne (author)
- Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
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- Ekerfelt, Christina (author)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Berg, Göran (author)
- Östergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping
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- Nieminen, Katri (author)
- Linköpings universitet,Institutionen för molekylär och klinisk medicin,Hälsouniversitetet
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- Sharma, Surendra (author)
- Departments of Pediatrics and Pathology, Brown University and Women and Infants' Hospital of Rhode Island, Providence, RI, USA
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- Ernerudh, Jan (author)
- Östergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin
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(creator_code:org_t)
- 2004-03-16
- 2004
- English.
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In: American Journal of Reproductive Immunology. - : John Wiley & Sons. - 1046-7408 .- 1600-0897. ; 51:4, s. 302-310
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Problem: A Th1-shift has been suggested to be involved in the pathogenesis of preeclampsia. This study was designed to compare Th1/Th2 related cytokine secretion in blood between women with preeclampsia (n = 15) and normal pregnancies (n = 15), using a high-sensitivity technique for cytokine detection.Methods of study: Spontaneous as well as 'fetus-specific' and recall antigen-specific (purified protein derivate of Mycobacterium tuberculosis, tetanus toxoid and lipopolysaccharide) secretion of interferon-γ, interleukin (IL)-4, IL-10 and IL-12 in peripheral blood mononuclear cells (PBMC) was detected by enzyme-linked immunosorbent spot-forming cell assay (ELISPOT). Fetus-specific secretion was induced by stimulation with paternal PBMC in a mixed leukocyte culture assay.Results: All cytokines were secreted by PBMCs both from women with preeclampsia and women with normal pregnancies. No differences in the number of cytokine-secreting cells were found between the two groups.Conclusions: No evidence was found for a shift in the systemic Th1/Th2 responses, in preeclampsia compared with normal pregnancy. This does, however, not exclude differences in the local immune responses related to the fetoplacental unit.
Keyword
- ELISPOT
- interferon-γ
- interleukin-10
- interleukin-12
- interleukin-4
- preeclampsia
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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