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  • Andersson, EvelynKarolinska Institutet,Karolinska Institutet, Stockholm, Sweden (författare)

Genetic Polymorphisms in Monoamine Systems and Outcome of Cognitive Behavior Therapy for Social Anxiety Disorder

  • Artikel/kapitelEngelska2013

Förlag, utgivningsår, omfång ...

  • 2013-11-15
  • Public Library of Science (PLoS),2013
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:su-96608
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-96608URI
  • https://doi.org/10.1371/journal.pone.0079015DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-213684URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:127969145URI
  • https://gup.ub.gu.se/publication/190917URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-102148URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • This study was sponsored by grants from the Swedish Research Council and the Stockholm County CouncilN. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
  • ObjectiveThe role of genetics for predicting the response to cognitive behavior therapy (CBT) for social anxiety disorder (SAD) has only been studied in one previous investigation. The serotonin transporter (5-HTTLPR), the catechol-o-methyltransferase (COMT) val158met, and the tryptophan hydroxylase-2 (TPH2) G-703Tpolymorphisms are implicated in the regulation of amygdala reactivity and fear extinction and therefore might be of relevance for CBT outcome. The aim of the present study was to investigate if these three gene variants predicted response to CBT in a large sample of SAD patients.MethodParticipants were recruited from two separate randomized controlled CBT trials (trial 1: n = 112, trial 2: n = 202). Genotyping were performed on DNA extracted from blood or saliva samples. Effects were analyzed at follow-up (6 or 12 months after treatment) for both groups and for each group separately at post-treatment. The main outcome measure was the Liebowitz Social Anxiety Scale Self-Report.ResultsAt long-term follow-up, there was no effect of any genotype, or gene × gene interactions, on treatment response. In the subsamples, there was time by genotype interaction effects indicating an influence of the TPH2 G-703T-polymorphism on CBT short-term response, however the direction of the effect was not consistent across trials.ConclusionsNone of the three gene variants, 5-HTTLPR, COMTval158met and TPH2 G-703T, was associated with long-term response to CBT for SAD.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Rück, ChristianKarolinska Institutet,Karolinska Institutet, Stockholm, Sweden (författare)
  • Lavebratt, CatharinaKarolinska Institutet,Karolinska Institutet, Stockholm, Sweden (författare)
  • Hedman, ErikKarolinska Institutet,Karolinska Institutet, Stockholm, Sweden (författare)
  • Schalling, MartinKarolinska Institutet,Karolinska Institutet, Stockholm, Sweden (författare)
  • Lindefors, NilsKarolinska Institutet,Karolinska Institutet, Stockholm, Sweden (författare)
  • Eriksson, Elias,1956Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,Sahlgrenska Academy, University of Gothenburg, Sweden(Swepub:gu)xereli (författare)
  • Carlbring, PerStockholms universitet,Psykologiska institutionen,Stockholm University, Sweden(Swepub:su)pecar (författare)
  • Andersson, Gerhard,1966-Linköpings universitet,Karolinska Institutet,Psykologi,Filosofiska fakulteten,Karolinska Institutet, Stockholm, Sweden,Internet, health and clinical psychology research group(Swepub:liu)geran87 (författare)
  • Furmark, TomasUppsala universitet,Institutionen för psykologi,Uppsala University, Sweden(Swepub:uu)tomafurm (författare)
  • Karolinska InstitutetKarolinska Institutet, Stockholm, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:PLOS ONE: Public Library of Science (PLoS)8:111932-6203

Internetlänk

Hitta via bibliotek

  • PLOS ONE (Sök värdpublikationen i LIBRIS)

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