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Decreased medial te...
Decreased medial temporal lobe activation in BDNF 66Met allele carriers during memory encoding
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- Kauppi, Karolina, 1985- (author)
- Umeå universitet,Fysiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Nilsson, Lars-Göran (author)
- Stockholms universitet,Psykologiska institutionen,Stockholm University
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- Adolfsson, Rolf (author)
- Umeå universitet,Psykiatri
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- Lundquist, Anders (author)
- Umeå universitet,Statistik,Fysiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Eriksson, Elias, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
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- Nyberg, Lars (author)
- Umeå universitet,Fysiologi,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi
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(creator_code:org_t)
- Elsevier, 2013
- 2013
- English.
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In: Neuropsychologia. - : Elsevier. - 0028-3932 .- 1873-3514. ; 51:12, s. 2462-2468
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Subject headings
Close
- The Met allele of the Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has been associated with impaired activity-dependent secretion of BDNF protein and decreased memory performance. Results from imaging studies relating Val66Met to brain activation during memory processing have been inconsistent, with reports of both increased and decreased activation in the Medial Temporal Lobe (MTL) in Met carriers relative to Val homozygotes. Here, we extensively studied BDNF Val66Met in relation to brain activation and white matter integrity as well as memory performance in a large imaging (n=194) and behavioral (n=2229) sample, respectively. Functional magnetic resonance imaging (fMRI) was used to investigate MTL activation in healthy participants in the age of 55–75 years during a face-name episodic encoding and retrieval task. White matter integrity was measured using diffusion tensor imaging.BDNF Met allele carriers had significantly decreased activation in the MTL during encoding processes, but not during retrieval processes. In contrast to previous proposals, the effect was not modulated by age and the polymorphism was not related to white matter integrity. Met carriers had lower memory performance than Val homozygotes, but differences were subtle and not significant. In conclusion, the BDNF Met allele has a negative influence on MTL functioning, preferentially during encoding processes, which might translate into impaired episodic memory function.
Subject headings
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- imaging
- genetics
- memory
- Val66Met
- parahippocampus
- Psychology
- psykologi
- Physiology
- lobe activation BDNF66Met allele memory
Publication and Content Type
- ref (subject category)
- art (subject category)
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