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- Skiöld, SaraStockholms universitet,Institutionen för molekylärbiologi och funktionsgenomik (author)
Low doses of γ-radiation induce consistent protein expression changes in human leukocytes
- Article/chapterEnglish2011
Publisher, publication year, extent ...
- Inderscience Publishers,2011
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:su-97111
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-97111URI
- https://doi.org/10.1504/IJLR.2011.047188DOI
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- Language:English
- Summary in:English
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Notes
- Twenty percent of cancer patients experience adverse effects after radiotherapy. The therapeutic doses are adjusted to the most sensitive individuals, resulting in a suboptimal dose for many patients. At present there is no screening system available to predict individual radiosensitivity. The main aim of this study is to investigate differences in protein expression pathways induced by low doses of radiation in whole blood obtained from radiosensitive and non–radiosensitive patients. To address this aim, a protocol for exposure condition, dose and analysis of whole blood was developed. The conditions for handling blood samples were optimised. The optimal doses and post irradiation conditions were determined. We found that 1 mGy and 150 mGy significantly changed protein expression in leukocytes collected from the two donors. The result shows that the protocol developed is suitable for characterisation of proteomic profiles associated with low dose exposure of leukocytes.
Subject headings and genre
- NATURVETENSKAP Biologi Cellbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Cell Biology hsv//eng
- NATURVETENSKAP Biologi Annan biologi hsv//swe
- NATURAL SCIENCES Biological Sciences Other Biological Topics hsv//eng
- low dose radiation; Oxidative stress; proteomics; whole blood; gamma radiation
- Molecular Biology
- molekylärbiologi
Added entries (persons, corporate bodies, meetings, titles ...)
- Becker, SusanneKarolinska University Hospital (author)
- Hellman, UlfUppsala University (author)
- Auer, GertKarolinska University Hospital (author)
- Näslund, IngemarKarolinska University Hospital (author)
- Harms-Ringdahl, MatsStockholms universitet,Institutionen för molekylärbiologi och funktionsgenomik(Swepub:su)ringdahl (author)
- Haghdoost, SiamakStockholms universitet,Institutionen för molekylärbiologi och funktionsgenomik(Swepub:su)shagh (author)
- Stockholms universitetInstitutionen för molekylärbiologi och funktionsgenomik (creator_code:org_t)
Related titles
- In:International Journal of Low RadiationInderscience Publishers8:5/6, s. 374-3871477-65451741-9190
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