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Hepatocellular and ...
Hepatocellular and extrahepatic cancer in patients with autoimmune hepatitis : a long-term follow-up study in 634 Swedish patients
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- Danielsson Borssén, Åsa (author)
- Umeå universitet,Medicin,Departments of Medicine, Sections for Hepatology and Gastroenterology, Umeå University Hospital, Umeå, Sweden
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- Almer, Sven (author)
- Karolinska Institutet
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- Prytz, Hanne (author)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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Wallerstedt, Sven (author)
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Friis-Liby, Inga-Lill (author)
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- Bergquist, Annika (author)
- Karolinska Institutet
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Nyhlin, Nils (author)
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- Hultcrantz, Rolf (author)
- Karolinska Institutet
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- Sangfelt, Per (author)
- Uppsala universitet,Gastroenterologi/hepatologi
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- Weiland, Ola (author)
- Karolinska Institutet
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- Lindgren, Stefan (author)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups
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- Verbaan, Hans (author)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups
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- Werner, Mårten (author)
- Umeå universitet,Medicin,Departments of Medicine, Sections for Hepatology and Gastroenterology, Umeå University Hospital, Umeå, Sweden
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(creator_code:org_t)
- 2014-12-08
- 2015
- English.
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In: Scandinavian Journal of Gastroenterology. - : Informa Healthcare. - 0036-5521 .- 1502-7708. ; 50:2, s. 217-223
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http://dx.doi.org/10...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Objectives. Cirrhosis is a well-known risk factor for hepatocellular cancer, but the true risk in autoimmune hepatitis (AIH) is scarcely studied. Other cancers may arise after prolonged use of immune-modulating drugs. The aim of this study was to investigate the cancer risk in a large cohort of AIH patients.Material and methods. Six hundred and thirty-four Swedish patients in a well-defined cohort were matched to the Cause of Death Registry and the Cancer Registry. Standard incidence ratios were calculated by relating the incidences in the cohort to an age-matched material from the Swedish background population.Results. A higher overall incidence of malignancies than the background population was found, counting from the date of diagnosis (standard incidence ratio (SIR) 2.08, 95% CI 1.68-2.55). The highest risk was found for hepatocellular carcinoma (HCC). We found 10 cases (4.0%) in 248 patients with cirrhosis, which gives an incidence rate of 0.3%. Standard incidence ratio for developing hepatobiliary cancer was 54.55 (95% CI 19.92-99.99). HCC only occurred in cirrhotic patients. There was also an increased risk for non-melanoma skin cancer (SIR 9.87, 95% CI 6.26-14.81).Conclusion. A slightly enhanced risk for malignancies in general compared to the background population was found. The risk of hepatobiliary cancer was increased, but the annual risk over the observational period was well under the postulated 1.5% when surveillance in cirrhotic patients is considered to be cost-effective.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- autoimmune hepatitis
- autoimmune liver disease
- cancer
- extrahepatic cancer
- hepatocellular rcinoma
- hepatocellular carcinoma
- extrahepatic
- cancer
- autoimmune hepatitis
- autoimmune liver disease
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Danielsson Borss ...
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Almer, Sven
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Prytz, Hanne
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Wallerstedt, Sve ...
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Friis-Liby, Inga ...
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Bergquist, Annik ...
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show more...
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Nyhlin, Nils
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Hultcrantz, Rolf
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Sangfelt, Per
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Weiland, Ola
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Lindgren, Stefan
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Verbaan, Hans
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Werner, Mårten
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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MEDICAL AND HEAL ...
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- Articles in the publication
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Scandinavian Jou ...
- By the university
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Umeå University
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Lund University
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Karolinska Institutet
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Uppsala University