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  • Jalali, Ali (author)

Targeted sequencing in chromosome 17q linkage region identifies familial glioma candidates in the Gliogene Consortium

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2015-02-05
  • Nature Publishing Group,2015
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-100279
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100279URI
  • https://doi.org/10.1038/srep08278DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Glioma is a rare, but highly fatal, cancer that accounts for the majority of malignant primary brain tumors. Inherited predisposition to glioma has been consistently observed within non-syndromic families. Our previous studies, which involved non-parametric and parametric linkage analyses, both yielded significant linkage peaks on chromosome 17q. Here, we use data from next generation and Sanger sequencing to identify familial glioma candidate genes and variants on chromosome 17q for further investigation. We applied a filtering schema to narrow the original list of 4830 annotated variants down to 21 very rare (<0.1% frequency), non-synonymous variants. Our findings implicate the MYO19 and KIF18B genes and rare variants in SPAG9 and RUNDC1 as candidates worthy of further investigation. Burden testing and functional studies are planned.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Amirian, E. Susan (author)
  • Bainbridge, Matthew N. (author)
  • Armstrong, Georgina N. (author)
  • Liu, Yanhong (author)
  • Tsavachidis, Spyros (author)
  • Jhangiani, Shalini N. (author)
  • Plon, Sharon E. (author)
  • Lau, Ching C. (author)
  • Claus, Elizabeth B. (author)
  • Barnholtz-Sloan, Jill S. (author)
  • Il'yasova, Dora (author)
  • Schildkraut, Joellen (author)
  • Ali-Osman, Francis (author)
  • Sadetzki, Siegal (author)
  • Johansen, Christoffer (author)
  • Houlston, Richard S. (author)
  • Jenkins, Robert B. (author)
  • Lachance, Daniel (author)
  • Olson, Sara H. (author)
  • Bernstein, Jonine L. (author)
  • Merrell, Ryan T. (author)
  • Wrensch, Margaret R. (author)
  • Davis, Faith G. (author)
  • Lai, Rose (author)
  • Shete, Sanjay (author)
  • Aldape, Kenneth (author)
  • Amos, Christopher I. (author)
  • Muzny, Donna M. (author)
  • Gibbs, Richard A. (author)
  • Melin, Beatrice SUmeå universitet,Onkologi(Swepub:umu)bema0010 (author)
  • Bondy, Melissa L. (author)
  • Umeå universitetOnkologi (creator_code:org_t)

Related titles

  • In:Scientific Reports: Nature Publishing Group5, s. 8278-2045-2322

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