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Depot-specific mess...
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Li, X.Umeå universitet,Pediatrik
(författare)
Depot-specific messenger RNA expression of 11 beta-hydroxysteroid dehydrogenase type 1 and leptin in adipose tissue of children and adults
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
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2006-10-24
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London :Macmillan,2007
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-10073
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-10073URI
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https://doi.org/10.1038/sj.ijo.0803470DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-144948URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Objective: To compare expression of messenger RNA (mRNA) coding for the cortisol regenerating enzyme 11-hydroxysteroid dehydrogenase type 1 (11-HSD1), and the adipocytokines leptin and resistin in paired biopsies of subcutaneous adipose tissue (SC) and omental adipose tissue (OM) from children. Design: Paired biopsies (SC and OM) were obtained from 54 children (age 0.17–16 years, body mass index (BMI) 12.5–28.3 kg/m2, BMI standard deviation score (SDS) -2.5–4.5) and 16 adults (age 27–79 years, BMI 19–46 kg/m2) undergoing open abdominal surgery. mRNA levels of 11-HSD1, leptin and resistin were measured using quantitative real-time polymerase chain reaction (PCR). Results: 11-HSD1 mRNA level was higher in OM than in SC (P<0.05), whereas leptin mRNA was higher in SC than in OM (P<0.001). There was no difference in the resistin mRNA level between SC and OM. These results were consistent in children and adults. In children, 11-HSD1 mRNA in SC was positively associated with BMI SDS (P<0.05), whereas in OM it was positively associated with age (P<0.05). The association between 11-HSD1 expression and age remained significant after adjustment for BMI SDS and gender. Leptin mRNA was positively associated with BMI SDS (SC:P<0.001, OM: P<0.001) but not with age in children. In multiple regression analyses, including anthropometric variables and age, BMI SDS was independently associated with mRNA levels of 11-HSD1 (P<0.05) and leptin (P<0.001) in SC. When normal weight and overweight children were analyzed separately, 11-HSD1 mRNA levels were positively associated with leptin in OM in the overweight group (P<0.05). Conclusion: There are depot-specific differences in mRNA levels of 11-HSD1 and leptin in children and adults. The positive association of 11-HSD1 mRNA in OM with age may reflect a causal role in visceral fat accumulation during growth. Increasing 11-HSD1 and leptin mRNA in SC with increasing BMI SDS could suggest that the risk of metabolic consequences of obesity may be established early in life.
Ämnesord och genrebeteckningar
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11-beta-Hydroxysteroid Dehydrogenase Type 1/*genetics
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Adipose Tissue/enzymology/*pathology
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Adolescent
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Adult
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Aged
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Aging/genetics
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Anthropometry
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Body Mass Index
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Child
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Child; Preschool
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Female
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Humans
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Infant
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Leptin/*genetics
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Male
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Middle Aged
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Obesity/*genetics
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Overweight/*genetics
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RNA; Messenger/*genetics
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Regression Analysis
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Resistin/*genetics
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MEDICINE
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Lindquist, SusanneUmeå universitet,Pediatrik(Swepub:umu)suli0001
(författare)
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Chen, R.Children's Research Institute of Nanjing Medical University, Nanjing, China
(författare)
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Myrnäs, TorbjörnUmeå universitet,Kirurgi(Swepub:umu)tomy0002
(författare)
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Angsten, GertrudUppsala universitet,Barnkirurgi(Swepub:uu)gertmagn
(författare)
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Olsson, TommyUmeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)tool0003
(författare)
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Hernell, OlleUmeå universitet,Pediatrik(Swepub:umu)olhe0002
(författare)
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Umeå universitetPediatrik
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of ObesityLondon : Macmillan31:5, s. 820-8280307-05651476-5497
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