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Investigation of Di...
Investigation of Dietary Factors and Endometrial Cancer Risk Using a Nutrient-wide Association Study Approach in the EPIC and Nurses' Health Study (NHS) and NHSII
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Merritt, Melissa A. (author)
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Tzoulaki, Ioanna (author)
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Tworoger, Shelley S. (author)
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De Vivo, Immaculata (author)
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Hankinson, Susan E. (author)
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Fernandes, Judy (author)
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Tsilidis, Konstantinos K. (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Tjonneland, Anne (author)
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Petersen, Kristina E. N. (author)
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Dahm, Christina C. (author)
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Overvad, Kim (author)
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Dossus, Laure (author)
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Boutron-Ruault, Marie-Christine (author)
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Fagherazzi, Guy (author)
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Fortner, Renee T. (author)
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Kaaks, Rudolf (author)
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Aleksandrova, Krasimira (author)
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Boeing, Heiner (author)
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Trichopoulou, Antonia (author)
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Bamia, Christina (author)
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Trichopoulos, Dimitrios (author)
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Palli, Domenico (author)
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Grioni, Sara (author)
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Tumino, Rosario (author)
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Sacerdote, Carlotta (author)
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Mattiello, Amalia (author)
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Bueno-de-Mesquita, H. B. (as) (author)
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Onland-Moret, N. Charlotte (author)
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Peeters, Petra H. (author)
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Gram, Inger T. (author)
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Skeie, Guri (author)
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Ramon Quiros, J. (author)
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Duell, Eric J. (author)
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Sanchez, Maria-Jose (author)
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Salmeron, D. (author)
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Barricarte, Aurelio (author)
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Chamosa, Saioa (author)
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Ericson, Ulrica (author)
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- Sonestedt, Emily (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Nilsson, Lena Maria (author)
- Umeå universitet,Arktiskt centrum vid Umeå universitet (Arcum),Näringsforskning
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- Idahl, Annika (author)
- Umeå universitet,Obstetrik och gynekologi
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Khaw, Kay-Tee (author)
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Wareham, Nicholas (author)
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Travis, Ruth C. (author)
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Rinaldi, Sabina (author)
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Romieu, Isabelle (author)
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Patel, Chirag J. (author)
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Riboli, Elio (author)
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Gunter, Marc J. (author)
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(creator_code:org_t)
- 2015
- 2015
- English.
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In: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965 .- 1538-7755. ; 24:2, s. 466-471
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
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- Data on the role of dietary factors in endometrial cancer development are limited and inconsistent. We applied a "nutrient-wide association study" approach to systematically evaluate dietary risk associations for endometrial cancer while controlling for multiple hypothesis tests using the false discovery rate (FDR) and validating the results in an independent cohort. We evaluated endometrial cancer risk associations for dietary intake of 84 foods and nutrients based on dietary questionnaires in three prospective studies, the European Prospective Investigation into Cancer and Nutrition (EPIC; N = 1,303 cases) followed by validation of nine foods/nutrients (FDR <= 0.10) in the Nurses' Health Studies (NHS/NHSII; N = 1,531 cases). Cox regression models were used to estimate HRs and 95% confidence intervals (CI). In multivariate adjusted comparisons of the extreme categories of intake at baseline, coffee was inversely associated with endometrial cancer risk (EPIC, median intake 750 g/day vs. 8.6; HR, 0.81; 95% CI, 0.68-0.97, P-trend = 0.09; NHS/NHSII, median intake 1067 g/day vs. none; HR, 0.82; 95% CI, 0.70-0.96, P-trend = 0.04). Eight other dietary factors that were associated with endometrial cancer risk in the EPIC study (total fat, monounsaturated fat, carbohydrates, phosphorus, butter, yogurt, cheese, and potatoes) were not confirmed in the NHS/NHSII. Our findings suggest that coffee intake may be inversely associated with endometrial cancer risk. Further data are needed to confirm these findings and to examine the mechanisms linking coffee intake to endometrial cancer risk to develop improved prevention strategies. (C)2015 AACR.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Merritt, Melissa ...
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Tzoulaki, Ioanna
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Tworoger, Shelle ...
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De Vivo, Immacul ...
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Hankinson, Susan ...
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Fernandes, Judy
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show more...
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Tsilidis, Konsta ...
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Weiderpass, Elis ...
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Tjonneland, Anne
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Petersen, Kristi ...
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Dahm, Christina ...
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Overvad, Kim
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Dossus, Laure
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Boutron-Ruault, ...
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Fagherazzi, Guy
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Fortner, Renee T ...
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Kaaks, Rudolf
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Aleksandrova, Kr ...
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Boeing, Heiner
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Trichopoulou, An ...
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Bamia, Christina
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Trichopoulos, Di ...
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Palli, Domenico
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Grioni, Sara
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Tumino, Rosario
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Sacerdote, Carlo ...
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Mattiello, Amali ...
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Bueno-de-Mesquit ...
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Onland-Moret, N. ...
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Peeters, Petra H ...
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Gram, Inger T.
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Skeie, Guri
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Ramon Quiros, J.
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Duell, Eric J.
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Sanchez, Maria-J ...
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Salmeron, D.
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Barricarte, Aure ...
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Chamosa, Saioa
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Ericson, Ulrica
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Sonestedt, Emily
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Nilsson, Lena Ma ...
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Idahl, Annika
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Khaw, Kay-Tee
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Wareham, Nichola ...
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Travis, Ruth C.
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Rinaldi, Sabina
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Romieu, Isabelle
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Patel, Chirag J.
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Riboli, Elio
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Gunter, Marc J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Epidemiol ...
- By the university
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Umeå University
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Lund University
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Karolinska Institutet