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Search: WFRF:(Wallensteen M) > (2010-2014) > CRYAB-650 C>G (rs22...

  • Sun, Chengjun (author)

CRYAB-650 C>G (rs2234702) affects susceptibility to type 1 diabetes and IAA-positivity in Swedish population

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • Elsevier,2012
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-101468
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-101468URI
  • https://doi.org/10.1016/j.humimm.2012.04.004DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:124840276URI
  • https://lup.lub.lu.se/record/81cb759b-e100-4a1d-bb69-4fa1150ec0bbURI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Single nucleotide polymorphisms (SNPs) in the promoter region of CRYAB gene have been associated with in multiple sclerosis. CRYAB gene, which encodes alpha B-crystallin (a member of small heat shock protein), was reported as a potential autoimmune target. In this study we investigated whether SNPs in the promoter region of CRYAB gene were also important in the etiology of Type 1 diabetes (T1D).METHODS: Genotyping of SNPs in the promoter region of CRYAB gene was performed in a Swedish cohort containing 444 T1D patients and 350 healthy controls. Three SNPs were included in this study: CRYAB-652 A>G (rs762550), -650 C>G (rs2234702) and -249 C > G (rs14133). Two SNPs (CRYAB-652 and -650) were not included in previous genome wide association studies.RESULTS: CRYAB-650 (rs2234702)*C allele was significantly more frequent in patients than in controls (OR = 1.48, Pc = 0.03). CRYAB-650*C allele was associated with IAA positivity (OR = 8.17, Pc < 0.0001) and IA-2A positivity (OR = 2.14, Pc = 0.005) in T1D patients. This association with IAA was amplified by high-risk HLA carrier state (OR = 10.6, P < 0.0001). No association was found between CRYAB-650 and other autoantibody positivity (GADA and ICA). CRYAB haplotypes were also associated with IAA and IA-2A positivity (highest OR = 2.07 and 2.11, respectively), these associations remain in high HLA-risk T1D patients.CONCLUSIONS: CRYAB-650 was associated with T1D in the Swedish cohort we studied. CRYAB-650*C allele might confers susceptibility to the development of T1D. CRYAB-650 was also associated with the development of IAA-positivity in T1D patients, especially in those carrying T1D high-risk HLA haplotypes.

Subject headings and genre

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  • Sedimbi, Saikiran KKarolinska Institutet (author)
  • Ashok, Ayyappa K (author)
  • Sanjeevi, Carani BKarolinska Institutet (author)
  • Lernmark, ÅkeLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,University of Washington(Swepub:lu)endo-ale(author)
  • Landin-Olsson, MonaLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-mla(author)
  • Arnqvist, Hans(author)
  • Björck, Elisabeth(author)
  • Eriksson, JanUmeå universitet,Medicin(Swepub:umu)jaer0001(author)
  • Nyström, LennarthUmeå universitet,Epidemiologi och global hälsa(Swepub:umu)leny0002(author)
  • Ohlson, Lars Olof(author)
  • Scherstén, BengtLund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups(Swepub:lu)smi-bsc(author)
  • Östman, Jan(author)
  • Aili, M(author)
  • Bååth, LE(author)
  • Carlsson, E(author)
  • Edenwall, H(author)
  • Forsander, G(author)
  • Granström, BW(author)
  • Gustavsson, I(author)
  • Hanås, R(author)
  • Hellenberg, L(author)
  • Hellgren, H(author)
  • Holmberg, EUmeå universitet,Pediatrik(author)
  • Hörnell, H(author)
  • Ivarsson, Sten-ALund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Pediatrisk endokrinologi,Celiac Disease and Diabetes Unit,Lund University Research Groups,Paediatric Endocrinology(Swepub:lu)pedi-siv(author)
  • Johansson, C(author)
  • Jonsell, G(author)
  • Kockum, K(author)
  • Lindblad, B(author)
  • Lindh, A(author)
  • Ludvigsson, J(author)
  • Myrdal, U(author)
  • Neiderud, J(author)
  • Segnestam, K(author)
  • Sjöblad, S.Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)st6585sj(author)
  • Skogsberg, L(author)
  • Strömberg, L(author)
  • Ståhle, U(author)
  • Thalme, B(author)
  • Tullus, K(author)
  • Tuvemo, T(author)
  • Wallensteen, M(author)
  • Westphal, O(author)
  • Dahlquist, GiselaUmeå universitet,Pediatrik(Swepub:umu)gida0001(author)
  • Åman, J(author)
  • Karolinska InstitutetCeliaki och diabetes (creator_code:org_t)
  • Swedish Childhood Diabetes and the Diabetes Incidence in Sweden Study Groups

Related titles

  • In:Human Immunology: Elsevier73:7, s. 759-7660198-88591879-1166

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