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  • Mondul, Alison M. (author)

Vitamin D-Associated Genetic Variation and Risk of Breast Cancer in the Breast and Prostate Cancer Cohort Consortium (BPC3)

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2015
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-102376
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102376URI
  • https://doi.org/10.1158/1055-9965.EPI-14-1127DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:130963189URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Two recent genome-wide association studies (GWAS) identified SNPs in or near four genes related to circulating 25-hydroxyvitamin D [25(OH) D] concentration. To examine the hypothesized inverse relationship between vitamin D status and breast cancer, we studied the associations between SNPs in these genes and breast cancer risk in a large pooled study of 9,456 cases and 10,816 controls from six cohorts. Methods: SNP markers localized to each of four genes (GC, CYP24A1, CYP2R1, and DHCR7) previously associated with 25 (OH) D were genotyped and examined both individually and as a 4-SNP polygenic score. Logistic regression was used to estimate the associations between the genetic variants and risk of breast cancer. Results: We found no association between any of the four SNPs or their polygenic score and breast cancer risk. Conclusions: Our findings do not support an association between vitamin D status, as reflected by 25(OH) D-related genotypes, and breast cancer risk. Impact: These findings may contribute to future meta-analyses and scientific review articles, and provide new data about the association between vitamin D-related genes and breast cancer.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Shui, Irene M. (author)
  • Yu, Kai (author)
  • Weinstein, Stephanie J. (author)
  • Tsilidis, Konstantinos K. (author)
  • Joshi, Amit D. (author)
  • Agudo, Antonio (author)
  • Berg, Christine D. (author)
  • Black, Amanda (author)
  • Buring, Julie E. (author)
  • Chasman, Daniel I. (author)
  • Gaudet, Mia M. (author)
  • Haiman, Christopher (author)
  • Hankinson, Susan E. (author)
  • Henderson, Brian E. (author)
  • Hoover, Robert N. (author)
  • Hunter, David J. (author)
  • Khaw, Kay-Tee (author)
  • Kuehn, Tilman (author)
  • Kvaskoff, Marina (author)
  • Le Marchand, Loic (author)
  • Lindstroem, Sara (author)
  • McCullough, Marjorie L. (author)
  • Overvad, Kim (author)
  • Peeters, Petra H. (author)
  • Riboli, Elio (author)
  • Ridker, Paul M. (author)
  • Stram, Daniel O. (author)
  • Sund, MalinUmeå universitet,Kirurgi(Swepub:umu)masu0021 (author)
  • Trichopoulos, Dimitrios (author)
  • Tumino, Rosario (author)
  • Weiderpass, ElisabeteKarolinska Institutet (author)
  • Willett, Walter (author)
  • Kraft, Peter (author)
  • Ziegler, Regina G. (author)
  • Albanes, Demetrius (author)
  • Umeå universitetKirurgi (creator_code:org_t)

Related titles

  • In:Cancer Epidemiology, Biomarkers and Prevention24:3, s. 627-6301055-99651538-7755

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