Search: (WFRF:(Fraumeni Joseph R. Jr.)) pers:(Figueroa Jonine D) pers:(Rothman Nathaniel) >
Characterization of...
Characterization of Large Structural Genetic Mosaicism in Human Autosomes
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Machiela, Mitchell J. (author)
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Zhou, Weiyin (author)
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Sampson, Joshua N. (author)
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show more...
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Dean, Michael C. (author)
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Jacobs, Kevin B. (author)
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Black, Amanda (author)
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Brinton, Louise A. (author)
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Chang, I-Shou (author)
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Chen, Chu (author)
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Chen, Constance (author)
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Chen, Kexin (author)
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Cook, Linda S. (author)
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Bou, Marta Crous (author)
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De Vivo, Immaculata (author)
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Doherty, Jennifer (author)
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Friedenreich, Christine M. (author)
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Gaudet, Mia M. (author)
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Haiman, Christopher A. (author)
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Hankinson, Susan E. (author)
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Hartge, Patricia (author)
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Henderson, Brian E. (author)
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Hong, Yun-Chul (author)
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Hosgood, H. Dean, III (author)
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Hsiung, Chao A. (author)
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Hu, Wei (author)
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Hunter, David J. (author)
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Jessop, Lea (author)
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Kim, Hee Nam (author)
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Kim, Yeul Hong (author)
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Kim, Young Tae (author)
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Klein, Robert (author)
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Kraft, Peter (author)
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Lan, Qing (author)
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Lin, Dongxin (author)
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Liu, Jianjun (author)
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Le Marchand, Loic (author)
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Liang, Xiaolin (author)
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Lissowska, Jolanta (author)
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Lu, Lingeng (author)
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Magliocco, Anthony M. (author)
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Matsuo, Keitaro (author)
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Olson, Sara H. (author)
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Orlow, Irene (author)
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Park, Jae Yong (author)
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Pooler, Loreall (author)
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Prescott, Jennifer (author)
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Rastogi, Radhai (author)
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Risch, Harvey A. (author)
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Schumacher, Fredrick (author)
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Seow, Adeline (author)
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Setiawan, Veronica Wendy (author)
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Shen, Hongbing (author)
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Sheng, Xin (author)
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Shin, Min-Ho (author)
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Shu, Xiao-Ou (author)
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VanDen Berg, David (author)
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Wang, Jiu-Cun (author)
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Wentzensen, Nicolas (author)
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Wong, Maria Pik (author)
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Wu, Chen (author)
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Wu, Tangchun (author)
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Wu, Yi-Long (author)
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Xia, Lucy (author)
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Yang, Hannah P. (author)
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Yang, Pan-Chyr (author)
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Zheng, Wei (author)
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Zhou, Baosen (author)
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Abnet, Christian C. (author)
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Albanes, Demetrius (author)
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Aldrich, Melinda C. (author)
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Amos, Christopher (author)
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Amundadottir, Laufey T. (author)
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Berndt, Sonja I. (author)
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Blot, William J. (author)
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Bock, Cathryn H. (author)
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Bracci, Paige M. (author)
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Burdett, Laurie (author)
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Buring, Julie E. (author)
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Butler, Mary A. (author)
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Carreon, Tania (author)
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Chatterjee, Nilanjan (author)
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Chung, Charles C. (author)
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Cook, Michael B. (author)
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Cullen, Michael (author)
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Davis, Faith G. (author)
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Ding, Ti (author)
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Duell, Eric J. (author)
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Epstein, Caroline G. (author)
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Fan, Jin-Hu (author)
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Figueroa, Jonine D. (author)
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Fraumeni, Joseph F., Jr. (author)
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Freedman, Neal D. (author)
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Fuchs, Charles S. (author)
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Gao, Yu-Tang (author)
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Gapstur, Susan M. (author)
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Patino-Garcia, Ana (author)
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Garcia-Closas, Montserrat (author)
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Gaziano, J. Michael (author)
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Giles, Graham G. (author)
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Gillanders, Elizabeth M. (author)
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Giovannucci, Edward L. (author)
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Goldin, Lynn (author)
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Goldstein, Alisa M. (author)
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Greene, Mark H. (author)
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- Hallmans, Göran (author)
- Umeå universitet,Enheten för biobanksforskning,Näringsforskning
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Harris, Curtis C. (author)
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- Henriksson, Roger (author)
- Umeå universitet,Onkologi
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Holly, Elizabeth A. (author)
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Hoover, Robert N. (author)
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Hu, Nan (author)
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Hutchinson, Amy (author)
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Jenab, Mazda (author)
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Johansen, Christoffer (author)
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Khaw, Kay-Tee (author)
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Koh, Woon-Puay (author)
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Kolonel, Laurence N. (author)
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Kooperberg, Charles (author)
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Krogh, Vittorio (author)
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Kurtz, Robert C. (author)
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LaCroix, Andrea (author)
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Landgren, Annelie (author)
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Landi, Maria Teresa (author)
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Li, Donghui (author)
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Liao, Linda M. (author)
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Malats, Nuria (author)
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McGlynn, Katherine A. (author)
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McNeill, Lorna H. (author)
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McWilliams, Robert R. (author)
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Melin, Beatrice S. (author)
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Mirabello, Lisa (author)
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Peplonska, Beata (author)
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Peters, Ulrike (author)
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Petersen, Gloria M. (author)
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Prokunina-Olsson, Ludmila (author)
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Purdue, Mark (author)
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Qiao, You-Lin (author)
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Rabe, Kari G. (author)
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Rajaraman, Preetha (author)
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Real, Francisco X. (author)
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Riboli, Elio (author)
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Rodriguez-Santiago, Benjamin (author)
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Rothman, Nathaniel (author)
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Ruder, Avima M. (author)
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Savage, Sharon A. (author)
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Schwartz, Ann G. (author)
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Schwartz, Kendra L. (author)
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Sesso, Howard D. (author)
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Severi, Gianluca (author)
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Silverman, Debra T. (author)
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Spitz, Margaret R. (author)
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Stevens, Victoria L. (author)
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Stolzenberg-Solomon, Rachael (author)
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Stram, Daniel (author)
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Tang, Ze-Zhong (author)
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Taylor, Philip R. (author)
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Teras, Lauren R. (author)
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Tobias, Geoffrey S. (author)
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Viswanathan, Kala (author)
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Wacholder, Sholom (author)
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Wang, Zhaoming (author)
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Weinstein, Stephanie J. (author)
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Wheeler, William (author)
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White, Emily (author)
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Wiencke, John K. (author)
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Wolpin, Brian M. (author)
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Wu, Xifeng (author)
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Wunder, Jay S. (author)
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Yu, Kai (author)
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Zanetti, Krista A. (author)
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- Zeleniuch-Jacquotte, Anne (author)
- Umeå universitet,Enheten för biobanksforskning
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Ziegler, Regina G. (author)
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De Andrade, Mariza (author)
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Barnes, Kathleen C. (author)
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Beaty, Terri H. (author)
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Bierut, Laura J. (author)
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Desch, Karl C. (author)
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Doheny, Kimberly F. (author)
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Feenstra, Bjarke (author)
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Ginsburg, David (author)
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Heit, John A. (author)
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Kang, Jae H. (author)
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Laurie, Cecilia A. (author)
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Li, Jun Z. (author)
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Lowe, William L. (author)
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Marazita, Mary L. (author)
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Melbye, Mads (author)
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Mirel, Daniel B. (author)
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Murray, Jeffrey C. (author)
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Nelson, Sarah C. (author)
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Pasquale, Louis R. (author)
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Rice, Kenneth (author)
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Wiggs, Janey L. (author)
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Wise, Anastasia (author)
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Tucker, Margaret (author)
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Perez-Jurado, Luis A. (author)
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Laurie, Cathy C. (author)
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Caporaso, Neil E. (author)
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Yeager, Meredith (author)
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Chanock, Stephen J. (author)
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 96:3, s. 487-497
- Related links:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Analyses of genome-wide association study (GWAS) data have revealed that detectable genetic mosaicism involving large (>2 Mb) structural autosomal alterations occurs in a fraction of individuals. We present results for a set of 24,849 genotyped individuals (total GWAS set II [TGSII]) in whom 341 large autosomal abnormalities were observed in 168 (0.68%) individuals. Merging data from the new TGSII set with data from two prior reports (the Gene-Environment Association Studies and the total GWAS set I) generated a large dataset of 127,179 individuals; we then conducted a meta-analysis to investigate the patterns of detectable autosomal mosaicism (n = 1,315 events in 925 [0.73%] individuals). Restricting to events >2 Mb in size, we observed an increase in event frequency as event size decreased. The combined results underscore that the rate of detectable mosaicism increases with age (p value = 5.5 x 3 10(-31)) and is higher in men (p value = 0.002) but lower in participants of African ancestry (p value = 0.003). In a subset of 47 individuals from whom serial samples were collected up to 6 years apart, complex changes were noted over time and showed an overall increase in the proportion of mosaic cells as age increased. Our large combined sample allowed for a unique ability to characterize detectable genetic mosaicism involving large structural events and strengthens the emerging evidence of non-random erosion of the genome in the aging population.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Machiela, Mitche ...
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Zhou, Weiyin
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Sampson, Joshua ...
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Dean, Michael C.
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Jacobs, Kevin B.
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Black, Amanda
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show more...
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Brinton, Louise ...
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Chang, I-Shou
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Chen, Chu
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Chen, Constance
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Chen, Kexin
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Cook, Linda S.
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Bou, Marta Crous
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De Vivo, Immacul ...
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Doherty, Jennife ...
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Friedenreich, Ch ...
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Gaudet, Mia M.
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Haiman, Christop ...
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Hankinson, Susan ...
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Hartge, Patricia
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Henderson, Brian ...
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Hong, Yun-Chul
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Hosgood, H. Dean ...
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Hsiung, Chao A.
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Hu, Wei
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Hunter, David J.
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Jessop, Lea
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Kim, Hee Nam
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Kim, Yeul Hong
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Kim, Young Tae
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Klein, Robert
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Kraft, Peter
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Lan, Qing
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Lin, Dongxin
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Liu, Jianjun
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Le Marchand, Loi ...
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Liang, Xiaolin
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Lissowska, Jolan ...
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Lu, Lingeng
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Magliocco, Antho ...
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Matsuo, Keitaro
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Olson, Sara H.
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Orlow, Irene
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Park, Jae Yong
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Pooler, Loreall
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Prescott, Jennif ...
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Rastogi, Radhai
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Risch, Harvey A.
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Schumacher, Fred ...
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Seow, Adeline
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Setiawan, Veroni ...
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Shen, Hongbing
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Sheng, Xin
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Shin, Min-Ho
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Shu, Xiao-Ou
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VanDen Berg, Dav ...
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Wang, Jiu-Cun
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Wentzensen, Nico ...
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Wong, Maria Pik
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Wu, Chen
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Wu, Tangchun
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Wu, Yi-Long
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Xia, Lucy
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Yang, Hannah P.
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Yang, Pan-Chyr
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Zheng, Wei
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Zhou, Baosen
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Abnet, Christian ...
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Albanes, Demetri ...
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Aldrich, Melinda ...
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Amos, Christophe ...
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Amundadottir, La ...
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Berndt, Sonja I.
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Blot, William J.
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Bock, Cathryn H.
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Bracci, Paige M.
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Burdett, Laurie
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Buring, Julie E.
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Butler, Mary A.
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Carreon, Tania
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Chatterjee, Nila ...
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Chung, Charles C ...
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Cook, Michael B.
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Cullen, Michael
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Davis, Faith G.
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Ding, Ti
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Duell, Eric J.
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Epstein, Carolin ...
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Fan, Jin-Hu
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Figueroa, Jonine ...
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Fraumeni, Joseph ...
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Freedman, Neal D ...
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Fuchs, Charles S ...
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Gao, Yu-Tang
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Gapstur, Susan M ...
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Patino-Garcia, A ...
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Garcia-Closas, M ...
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Gaziano, J. Mich ...
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Giles, Graham G.
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Gillanders, Eliz ...
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Giovannucci, Edw ...
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Goldin, Lynn
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Goldstein, Alisa ...
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Greene, Mark H.
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Hallmans, Göran
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Harris, Curtis C ...
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Henriksson, Roge ...
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Holly, Elizabeth ...
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Hoover, Robert N ...
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Hu, Nan
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Hutchinson, Amy
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Jenab, Mazda
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Johansen, Christ ...
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Khaw, Kay-Tee
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Koh, Woon-Puay
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Kolonel, Laurenc ...
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Kooperberg, Char ...
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Krogh, Vittorio
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Kurtz, Robert C.
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LaCroix, Andrea
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Landgren, Anneli ...
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Landi, Maria Ter ...
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Li, Donghui
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Liao, Linda M.
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Malats, Nuria
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McGlynn, Katheri ...
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McNeill, Lorna H ...
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McWilliams, Robe ...
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Melin, Beatrice ...
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Mirabello, Lisa
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Peplonska, Beata
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Peters, Ulrike
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Petersen, Gloria ...
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Prokunina-Olsson ...
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Purdue, Mark
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Qiao, You-Lin
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Rabe, Kari G.
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Rajaraman, Preet ...
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Real, Francisco ...
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Riboli, Elio
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Rodriguez-Santia ...
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Rothman, Nathani ...
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Ruder, Avima M.
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Savage, Sharon A ...
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Schwartz, Ann G.
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Schwartz, Kendra ...
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Sesso, Howard D.
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Severi, Gianluca
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Silverman, Debra ...
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Spitz, Margaret ...
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Stevens, Victori ...
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Stolzenberg-Solo ...
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Stram, Daniel
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Tang, Ze-Zhong
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Taylor, Philip R ...
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Teras, Lauren R.
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Tobias, Geoffrey ...
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Viswanathan, Kal ...
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Wacholder, Sholo ...
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Wang, Zhaoming
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Weinstein, Steph ...
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Wheeler, William
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White, Emily
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Wiencke, John K.
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Wolpin, Brian M.
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Wu, Xifeng
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Wunder, Jay S.
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Yu, Kai
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Zanetti, Krista ...
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Zeleniuch-Jacquo ...
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Ziegler, Regina ...
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De Andrade, Mari ...
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Barnes, Kathleen ...
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Beaty, Terri H.
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Bierut, Laura J.
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Desch, Karl C.
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Doheny, Kimberly ...
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Feenstra, Bjarke
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Ginsburg, David
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Heit, John A.
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Kang, Jae H.
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Laurie, Cecilia ...
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Li, Jun Z.
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Lowe, William L.
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Marazita, Mary L ...
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Melbye, Mads
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Mirel, Daniel B.
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Murray, Jeffrey ...
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Nelson, Sarah C.
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Pasquale, Louis ...
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Rice, Kenneth
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Wiggs, Janey L.
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Wise, Anastasia
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Tucker, Margaret
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Perez-Jurado, Lu ...
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Laurie, Cathy C.
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Caporaso, Neil E ...
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Yeager, Meredith
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Chanock, Stephen ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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American Journal ...
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Umeå University