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Detection of Central Nervous System Involvement in Childhood Acute Lymphoblastic Leukemia by Cytomorphology and Flow Cytometry of the Cerebrospinal Fluid

Ranta, Susanna (författare)
Karolinska Institutet
Nilsson, Frans (författare)
Umeå universitet,Pediatrik
Harila-Saari, Arja (författare)
Karolinska Institutet
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Saft, Leonie (författare)
Karolinska Institutet
Tani, Edneia (författare)
Karolinska Institutet
Söderhall, Stefan (författare)
Karolinska Institutet
Porwit, Anna (författare)
Karolinska Institutet
Hultdin, Magnus (författare)
Umeå universitet,Patologi
Noren-Nyström, Ulrika (författare)
Umeå universitet,Pediatrik
Heyman, Mats (författare)
Karolinska Institutet
visa färre...
 (creator_code:org_t)
2014-12-24
2015
Engelska.
Ingår i: Pediatric Blood & Cancer. - : Wiley. - 1545-5009 .- 1545-5017. ; 62:6, s. 951-956
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Therapy directed at the central nervous system (CNS) is an essential part of the treatment for childhood acute lymphoblastic leukemia (ALL). The current evaluation of CNS involvement based on cytomorphological examination of the cerebrospinal fluid (CSF) alone is not as sensitive with low cell counts as flow cytometric immunophenotyping (FCI) of the CSF. However, the importance of low CSF blasts counts at diagnosis is uncertain. We sought to determine the significance of FCI in relation to conventional morphological examination.Procedure: We retrospectively compared FCI of the CSF with cytomorphology at diagnosis or relapse of childhood ALL. All patients were diagnosed 2000–2012 in Stockholm or Umeå, Sweden. Clinical data were collected from medical records and the Nordic leukemia registry. Treatment assignment was based on morphological examination only.Results: The cohort was comprised of 214 patients with ALL. CSF involvement was detected by both methods in 20 patients, in 17 by FCI alone, and in one patient by cytomorphology alone. The relapse rate was higher for patients with negative cytology but positive FCI compared to those without CNS involvement using both methods. The difference was especially marked in the current protocol. However, none of the patients with negative CSF cytology but positive FCI had a CNS relapse.Conclusions: FCI of the CSF increased the detection rate of CNS involvement of ALL approximately two times compared to cytomorphology. Patients with low-level CNS involvement may benefit from additional intensified systemic or CNS-directed therapy, but larger studies are needed. 

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

cerebrospinal fluid
cytology
flow cytometric immunophenotyping
leukemia

Publikations- och innehållstyp

ref (ämneskategori)
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