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Untargeted Metaboli...
Untargeted Metabolic Profiling Identifies Altered Serum Metabolites of Type 2 Diabetes Mellitus in a Prospective, Nested Case Control Study
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Drogan, Dagmar (author)
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Dunn, Warwick B. (author)
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Lin, Wanchang (author)
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Buijsse, Brian (author)
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Schulze, Matthias B. (author)
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Langenberg, Claudia (author)
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Brown, Marie (author)
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Floegel, Anna (author)
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Dietrich, Stefan (author)
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- Rolandsson, Olov (author)
- Umeå universitet,Allmänmedicin
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Wedge, David C. (author)
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Goodacre, Royston (author)
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Forouhi, Nita G. (author)
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Sharp, Stephen J. (author)
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Spranger, Joachim (author)
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Wareham, Nick J. (author)
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Boeing, Heiner (author)
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(creator_code:org_t)
- 2015-03-01
- 2015
- English.
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In: Clinical Chemistry. - : Oxford University Press (OUP). - 0009-9147 .- 1530-8561. ; 61:3, s. 487-497
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND:Application of metabolite profiling could expand the etiological knowledge of type 2 diabetes mellitus (T2D). However, few prospective studies apply broad untargeted metabolite profiling to reveal the comprehensive metabolic alterations preceding the onset of T2D. METHODS: We applied untargeted metabolite profiling in serum samples obtained from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort comprising 300 individuals who developed T2D after a median follow-up time of 6 years and 300 matched controls. For that purpose, we used ultraperformance LC-MS with a protocol specifically designed for large-scale metabolomics studies with regard to robustness and repeatability. After multivariate classification to select metabolites with the strongest contribution to disease classification, we applied multivariable-adjusted conditional logistic regression to assess the association of these metabolites with T2D.RESULTS: Among several alterations in lipid metabolism, there was an inverse association with T2D for metabolites chemically annotated as lysophosphatidylcholine(dm16:0) and phosphatidylcholine(O-20:0/O-20:0). Hexose sugars were positively associated with T2D, whereas higher concentrations of a sugar alcohol and a deoxyhexose sugar reduced the odds of diabetes by approximately 60% and 70%, respectively. Furthermore, there was suggestive evidence for a positive association of the circulating purine nucleotide isopentenyladenosine-5' -monophosphate with incident T2D.CONCLUSIONS: This study constitutes one of the largest metabolite profiling approaches of T2D biomarkers in a prospective study population. The findings might help generate new hypotheses about diabetes etiology and develop further targeted studies of a smaller number of potentially important metabolites. (C) 2014 American Association for Clinical Chemistry
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
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- By the author/editor
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Drogan, Dagmar
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Dunn, Warwick B.
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Lin, Wanchang
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Buijsse, Brian
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Schulze, Matthia ...
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Langenberg, Clau ...
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show more...
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Brown, Marie
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Floegel, Anna
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Dietrich, Stefan
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Rolandsson, Olov
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Wedge, David C.
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Goodacre, Roysto ...
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Forouhi, Nita G.
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Sharp, Stephen J ...
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Spranger, Joachi ...
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Wareham, Nick J.
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Boeing, Heiner
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Clinical Chemist ...
- By the university
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Umeå University