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Recent advances in ...
Recent advances in the research of an endemic osteochondropathy in China : Kashin-Beck disease
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- Guo, Xiong (författare)
- Institute of Endemic Diseases, School of Public Health, Xi'an Jiaotong University, Xi'an, China
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- Ma, Wei-Juan (författare)
- Institute of Endemic Diseases, School of Public Health, Xi'an Jiaotong University, Xi'an, China
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- Zhang, Feng (författare)
- Institute of Endemic Diseases, School of Public Health, Xi'an Jiaotong University, Xi'an, China
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- Ren, Feng-Lin (författare)
- Institute of Endemic Diseases, School of Public Health, Xi'an Jiaotong University, Xi'an, China
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- Qu, Cheng-Juan, 1967- (författare)
- Department of Applied Physics, University of Eastern Finland, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group
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- Lammi, Mikko, 1961- (författare)
- Department of Applied Physics, University of Eastern Finland, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group
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(creator_code:org_t)
- Elsevier, 2014
- 2014
- Engelska.
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Ingår i: Osteoarthritis and Cartilage. - : Elsevier. - 1063-4584 .- 1522-9653. ; 22:11, s. 1774-1783
- Relaterad länk:
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http://www.oarsijour...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Kashin-Beck disease (KBD) is an endemic chronic osteochondral disease, which has a high prevalence and morbidity in the Eastern Siberia of Russia, and in the broad diagonal, northern-east to southern-west belt in China and North Korea. In 1990's, it was estimated that in China 1–3 million people had some degree of symptoms of the disease, although even higher estimates have been presented. In China, the extensive prevalence peaked in the late 1950's, but since then, in contrast to the global trend of the osteoarthritis (OA), the number of cases has been dramatically falling. Up to 2013, there are 0.64 millions patients with the KBD and 1.16 millions at risk in 377 counties of 13 provinces or autonomous regions. This is obviously thanks to the preventive efforts carried out, which include providing millions of people with dietary supplements and clean water, as well as relocation of whole villages in China. However, relatively little is known about the molecular mechanisms behind the cartilage damage, the genetic and the environmental risk factors, and the rationale of the preventive effects. During the last decade, new data on a cellular and molecular level has begun to accumulate, which hopefully will uncover the grounds of the disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Kashin-Beck disease
- cartilage
- osteochondropathy
- gene expression
- proteomics
- ortopedi
- Orthopaedics
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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