Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits.

Nyckelord

Adenoviridae/genetics

Administration; Oral

Animals

Arteries

Cell Division/drug effects

Cell Movement

Combined Modality Therapy

Endothelium; Vascular/pathology

Enzyme Inhibitors/administration & dosage/*therapeutic use

Gene Transfer Techniques

Genetic Vectors/administration & dosage

Hypercholesterolemia/drug therapy/pathology/*therapy

Macrophages/immunology

Muscle; Smooth; Vascular/pathology

Piperazines/administration & dosage/*therapeutic use

Pyrimidines/administration & dosage/*therapeutic use

Rabbits

Receptors; Platelet-Derived Growth Factor/*antagonists & inhibitors

Research Support; Non-U.S. Gov't

Tunica Intima/cytology/drug effects/*pathology

Tunica Media/pathology

Vascular Endothelial Growth Factor C/*genetics

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)