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  • Commins, Scott P. (author)

The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-alpha-1,3-galactose

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • Elsevier BV,2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-104452
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-104452URI
  • https://doi.org/10.1016/j.jaci.2011.02.019DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: In 2009, we reported a novel form of delayed anaphylaxis to red meat that is related to serum IgE antibodies to the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal). Most of these patients had tolerated meat for many years previously. The implication is that some exposure in adult life had stimulated the production of these IgE antibodies. Objectives: We sought to investigate possible causes of this IgE antibody response, focusing on evidence related to tick bites, which are common in the region where these reactions occur.Methods: Serum assays were carried out with biotinylated proteins and extracts bound to a streptavidin ImmunoCAP.Results: Prospective studies on IgE antibodies in 3 subjects after tick bites showed an increase in levels of IgE to alpha-gal of 20fold or greater. Other evidence included (1) a strong correlation between histories of tick bites and levels of IgE to alpha-gal (chi(2) = 26.8, P < .001), (2) evidence that these IgE antibodies are common in areas where the tick Amblyomma americanum is common, and (3) a significant correlation between IgE antibodies to alpha-gal and IgE antibodies to proteins derived from A americanum (r(s) = 0.75, P < .001).Conclusion: The results presented here provide evidence that tick bites are a cause, possibly the only cause, of IgE specific for alpha-gal in this area of the United States. Both the number of subjects becoming sensitized and the titer of IgE antibodies to alpha-gal are striking. Here we report the first example of a response to an ectoparasite giving rise to an important form of food allergy.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • James, Hayley R. (author)
  • Kelly, Libby A. (author)
  • Pochan, Shawna L. (author)
  • Workman, Lisa J. (author)
  • Perzanowski, Matthew S. (author)
  • Kocan, Katherine M. (author)
  • Fahy, John V. (author)
  • Nganga, Lucy W. (author)
  • Rönmark, EvaUmeå universitet,Yrkes- och miljömedicin(Swepub:umu)evra0004 (author)
  • Cooper, Philip J. (author)
  • Platts-Mills, Thomas A. E. (author)
  • Umeå universitetYrkes- och miljömedicin (creator_code:org_t)

Related titles

  • In:Journal of Allergy and Clinical Immunology: Elsevier BV127:5, s. 1286-1293.e60091-67491097-6825

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