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The relevance of ti...
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Commins, Scott P.
(author)
The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-alpha-1,3-galactose
- Article/chapterEnglish2011
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Elsevier BV,2011
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-104452
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-104452URI
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https://doi.org/10.1016/j.jaci.2011.02.019DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: In 2009, we reported a novel form of delayed anaphylaxis to red meat that is related to serum IgE antibodies to the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal). Most of these patients had tolerated meat for many years previously. The implication is that some exposure in adult life had stimulated the production of these IgE antibodies. Objectives: We sought to investigate possible causes of this IgE antibody response, focusing on evidence related to tick bites, which are common in the region where these reactions occur.Methods: Serum assays were carried out with biotinylated proteins and extracts bound to a streptavidin ImmunoCAP.Results: Prospective studies on IgE antibodies in 3 subjects after tick bites showed an increase in levels of IgE to alpha-gal of 20fold or greater. Other evidence included (1) a strong correlation between histories of tick bites and levels of IgE to alpha-gal (chi(2) = 26.8, P < .001), (2) evidence that these IgE antibodies are common in areas where the tick Amblyomma americanum is common, and (3) a significant correlation between IgE antibodies to alpha-gal and IgE antibodies to proteins derived from A americanum (r(s) = 0.75, P < .001).Conclusion: The results presented here provide evidence that tick bites are a cause, possibly the only cause, of IgE specific for alpha-gal in this area of the United States. Both the number of subjects becoming sensitized and the titer of IgE antibodies to alpha-gal are striking. Here we report the first example of a response to an ectoparasite giving rise to an important form of food allergy.
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James, Hayley R.
(author)
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Kelly, Libby A.
(author)
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Pochan, Shawna L.
(author)
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Workman, Lisa J.
(author)
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Perzanowski, Matthew S.
(author)
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Kocan, Katherine M.
(author)
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Fahy, John V.
(author)
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Nganga, Lucy W.
(author)
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Rönmark, EvaUmeå universitet,Yrkes- och miljömedicin(Swepub:umu)evra0004
(author)
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Cooper, Philip J.
(author)
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Platts-Mills, Thomas A. E.
(author)
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Umeå universitetYrkes- och miljömedicin
(creator_code:org_t)
Related titles
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In:Journal of Allergy and Clinical Immunology: Elsevier BV127:5, s. 1286-1293.e60091-67491097-6825
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Commins, Scott P ...
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James, Hayley R.
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Kelly, Libby A.
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Pochan, Shawna L ...
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Workman, Lisa J.
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Perzanowski, Mat ...
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Kocan, Katherine ...
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Fahy, John V.
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Nganga, Lucy W.
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Rönmark, Eva
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Umeå University