Anastomotic leakage after surgery for rectal cancer: a risk factor for local recurrence, distant metastasis and reduced cancer-specific survival?

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Jörgren, FredrikLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups (författare)

Anastomotic leakage after surgery for rectal cancer : a risk factor for local recurrence, distant metastasis and reduced cancer-specific survival?

Artikel/kapitelEngelska2011

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2011-02-14
Wiley,2011
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-104492
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-104492URI
https://doi.org/10.1111/j.1463-1318.2009.02136.xDOI
https://lup.lub.lu.se/record/1511949URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:art swepub-publicationtype

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Aim The impact of anastomic leakage (AL) on the oncological outcome after anterior resection (AR) for rectal cancer is still controversial. We explored the impact of AL regarding local recurrence (LR), distant metastasis and overall recurrence (OAR). Overall and cancer-specific survival was analysed. Method Patients undergoing AR for rectal cancer with a registered AL between 1995 and 1997 and a control group were identified in the Swedish Rectal Cancer Registry. The medical records were retrieved for additional data and validation. Differences in the oncological outcome at 5-year follow-up were analysed with multivariate methods. Results After validation, 114 patients with AL and 136 control patients with locally radical surgery for tumours in tumour-node-metastasis stages I-III were analysed. There was no difference detected between patients with AL and control patients regarding rates of LR [8% (9 of 114) vs 9% (12 of 136); P = 0.97], distant metastasis [18% (20 of 114) vs 23% (31 of 136); P = 0.37] and OAR [19% (22 of 114) vs 28% (38 of 136); P = 0.15]. The 5-year cancer-specific survival was almost 80% in both groups. In multivariate analysis, AL was not a risk factor of LR, distant metastasis or OAR and had no impact on 5-year overall or 5-year cancer-specific survival. Irrespective of the occurrence of AL, preoperative radiotherapy (P = 0.055) and rectal washout (P = 0.046) reduced the LR rate, but did not influence survival. Conclusion Anastomotic leakage was not proved to be a risk factor of worse oncological outcome. Hence, additional adjuvant treatment or extended follow-up on the basis of the occurrence of AL after AR might not be justified.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
Rectal neoplasm
anterior resection
anastomosis
neoplasm recurrence
neoplasm metastasis
survival rate
survival rate
neoplasm metastasis
neoplasm recurrence
anastomosis
Rectal neoplasm
anterior resection

Biuppslag (personer, institutioner, konferenser, titlar ...)

Johansson, RobertUmeå universitet,Onkologi(Swepub:umu)rojo0001 (författare)
Damber, LenaUmeå universitet,Onkologi(Swepub:umu)leda0008 (författare)
Lindmark, GudrunLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)med-gli (författare)
KirurgiForskargrupper vid Lunds universitet (creator_code:org_t)

Sammanhörande titlar

Ingår i:Colorectal Disease: Wiley13:3, s. 272-2831462-89101463-1318

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Colorectal Disease (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Jörgren, Fredrik; Johansson, Rober ...; Damber, Lena; Lindmark, Gudrun

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kirurgi

Artiklar i publikationen: Colorectal Disea ...

Av lärosätet: Umeå universitet; Lunds universitet

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