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  • Madsen, Ida E.H.National Research Centre for the Working Environment, Copenhagen, Denmark,Department of Epidemiology and Public Health, University College London, London, United Kingdom (author)

Study protocol for examining job strain as a risk factor for severe unipolar depression in an individual participant meta-analysis of 14 European cohorts

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • 2014-02-26
  • F1000 Research Ltd,2014
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-105373
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-105373URI
  • https://doi.org/10.12688/f1000research.2-233.v2DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-24061URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-23629URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-106163URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-238854URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:224627793URI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • First version: Study protocol for examining job strain as a risk factor for severe unipolar depression in an individual participant meta-analysis of 14 European cohorts [version 1; peer review: 2 approved]. doi: 10.12688/f1000research.2-233.v1
  • Export Date: 7 January 2015
  • Background: Previous studies have shown that gainfully employed individuals with high work demands and low control at work (denoted "job strain") are at increased risk of common mental disorders, including depression. Most existing studies have, however, measured depression using self-rated symptom scales that do not necessarily correspond to clinically diagnosed depression. In addition, a meta-analysis from 2008 indicated publication bias in the field.Methods: This study protocol describes the planned design and analyses of an individual participant data meta-analysis, to examine whether job strain is associated with an increased risk of clinically diagnosed unipolar depression based on hospital treatment registers. The study will be based on data from approximately 120,000 individuals who participated in 14 studies on work environment and health in 4 European countries. The self-reported working conditions data will be merged with national registers on psychiatric hospital treatment, primarily hospital admissions. Study-specific risk estimates for the association between job strain and depression will be calculated using Cox regressions. The study-specific risk estimates will be pooled using random effects meta-analysis.Discussion: The planned analyses will help clarify whether job strain is associated with an increased risk of clinically diagnosed unipolar depression. As the analysis is based on pre-planned study protocols and an individual participant data meta-analysis, the pooled risk estimates will not be influenced by selective reporting and publication bias. However, the results of the planned study may only pertain to severe cases of unipolar depression, because of the outcome measure applied.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hannerz, HaraldFederal Institute for Occupational Safety and Health BAuA, Berlin, Germany,The Danish National Centre for Social Research, Copenhagen, DK-1052, Denmark,Stress Research Institute, Stockholm University, Stockholm, Sweden (author)
  • Theorell, TöresKarolinska Institutet,Stockholms universitet,Stressforskningsinstitutet(Swepub:su)ttheo (author)
  • Magnusson Hanson, Linda L.Stockholms universitet,Stressforskningsinstitutet(Swepub:su)linma (author)
  • Ahola, KirsiFinnish Institute of Occupational Health, Helsinki, Finland (author)
  • Alfredsson, LarsKarolinska Institutet (author)
  • Battt, G. DavidDepartment of Epidemiology and Public Health, University College London, London, United Kingdom (author)
  • Bjorner, Jakob B.National Research Centre for the Working Environment, Copenhagen, Denmark (author)
  • Borritz, MarianneDepartment of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark (author)
  • Burr, Hermann (author)
  • Dragano, NicoDepartment of Medical Sociology, University of Düsseldorf, Düsseldorf, Germany (author)
  • Ferrie, Jane E.Department of Epidemiology and Public Health, University College London, London, United Kingdom (author)
  • Hamer, Mark (author)
  • Westerholm, Peter J MUppsala universitet,Arbets- och miljömedicin(Swepub:uu)petwe427 (author)
  • Knutsson, AndersMittuniversitetet,Avdelningen för hälsovetenskap(Swepub:miun)andknu (author)
  • Koskenvuo, MarkkuDepartment of Public Health, University of Helsinki, Helsinki, Finland (author)
  • Koskinen, AkiFinnish Institute of Occupational Health, Helsinki, Finland (author)
  • Leineweber, ConstanzeStockholms universitet,Stressforskningsinstitutet(Swepub:su)clein (author)
  • Nielsen, Martin L.Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark (author)
  • Nordin, MariaUmeå universitet,Yrkes- och miljömedicin,Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, Umeå, Sweden(Swepub:umu)nonmaa98 (author)
  • Oksanen, TuulaFinnish Institute of Occupational Health, Helsinki, Finland (author)
  • Pejtersen, Jan H. (author)
  • Pentti, JaanaFinnish Institute of Occupational Health, Helsinki, Finland (author)
  • Salo, PaulaDepartment of Epidemiology and Public Health, University College London, London, United Kingdom (author)
  • Singh-Manoux, ArchanaDepartment of Epidemiology and Public Health, University College London, London, United Kingdom (author)
  • Suominen, SakariFolkhälsan Research Center, Helsinki, Finland,Finnish Institute of Occupational Health, Helsinki, Finland (author)
  • Theorell, Töres (author)
  • Toppinen-Tanner, Salla (author)
  • Vahtera, JussiFinnish Institute of Occupational Health, Helsinki, Finland (author)
  • Väänänen, AriFinnish Institute of Occupational Health, Helsinki, Finland (author)
  • Westerholm, Peter J. M. (author)
  • Westerlund, HugoUppsala universitet,Stockholms universitet,Stressforskningsinstitutet,Arbets- och miljömedicin,Eva Vingård(Swepub:su)hwest (author)
  • Fransson, EleonorJönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. ADULT(Swepub:hj)Frel (author)
  • Heikkilä, KatriinaFinnish Institute of Occupational Health, Helsinki, Finland (author)
  • Virtanen, MariannaFinnish Institute of Occupational Health, Helsinki, Finland (author)
  • Rugulies, ReinerNational Research Centre for the Working Environment, Copenhagen, Denmark (author)
  • Kivimäki, MikaFinnish Institute of Occupational Health, Helsinki, Finland (author)
  • National Research Centre for the Working Environment, Copenhagen, DenmarkDepartment of Epidemiology and Public Health, University College London, London, United Kingdom (creator_code:org_t)

Related titles

  • In:F1000 Research: F1000 Research Ltd22046-1402

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