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  • Mostafavi, Nahid (author)

Inflammatory markers in relation to long-term air pollution

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • Elsevier BV,2015
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-106310
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106310URI
  • https://doi.org/10.1016/j.envint.2015.04.003DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Long-term exposure to ambient air pollution can lead to chronic health effects such as cancer, cardiovascular and respiratory disease. Systemic inflammation has been hypothesized as a putative biological mechanism contributing to these adverse health effects. We evaluated the effect of long-term exposure to air pollution on blood markers of systemic inflammation. We measured a panel of 28 inflammatory markers in peripheral blood samples from 587 individuals that were biobanked as part of a prospective study. Participants were from Varese and Turin (Italy) and Umea (Sweden). Long-term air pollution estimates of nitrogen oxides (NOx) were available from the European Study of Cohorts for Air Pollution Effects (ESCAPE). Linear mixed models adjusted for potential confounders were applied to assess the association between NOx and the markers of inflammation. Long-term exposure to NO was associated with decreased levels of interleukin (IL)-2, IL-8, IL-10 and tumor necrosis factor-alpha in Italy, but not in Sweden. NOx exposure levels were considerably lower in Sweden than in Italy (Sweden: median (5th, 95th percentiles) 6.65 mu g/m(3) (4.8, 19.7); Italy: median (5th, 95th percentiles) 94.2 mu g/m(3) (7.8, 124.5)). Combining data from Italy and Sweden we only observed a significant association between long-term exposure to NOx and decreased levels of circulating IL-8. We observed some indication for perturbations in the inflammatory markers due to long-term exposure to NOx. Effects were stronger in Italy than in Sweden, potentially reflecting the difference in air pollution levels between the two cohorts.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Vlaanderen, Jelle (author)
  • Chadeau-Hyam, Marc (author)
  • Beelen, Rob (author)
  • Modig, LarsUmeå universitet,Yrkes- och miljömedicin(Swepub:umu)lasmog96 (author)
  • Palli, Domenico (author)
  • Bergdahl, Ingvar A.Umeå universitet,Yrkes- och miljömedicin,Enheten för biobanksforskning(Swepub:umu)inbe0001 (author)
  • Vineis, Paolo (author)
  • Hoek, Gerard (author)
  • Kyrtopoulos, Soterios A. (author)
  • Vermeulen, Roel (author)
  • Umeå universitetYrkes- och miljömedicin (creator_code:org_t)

Related titles

  • In:Environment International: Elsevier BV81, s. 1-70160-41201873-6750

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