Reversal of Heparin After Cardiac Surgery : Protamine Titration Using a Statistical Model

• Objective: To establish a statistical model for determination of protamine dose in conjunction with cardiopulmonary bypass. Design: Prospective.Setting: University hospital.Participants: Ninety consecutive cardiac surgical patients.Interventions: None.Measurements and Main Results: A series of clinically oriented variables were introduced into a statistical model for projection of the protamine dose after cardiopulmonary bypass. The following significant predictors were identified using multivariable regression analysis: The patient's body surface area, the administered dose of heparin, heparin clearance, and the preoperative platelet count. The statistical model projected the protamine dose within 3 +/- 23 mg of the point-of-care test used as reference.Conclusion: Protamine dosing based on statistical modeling represents an alternative to point-of-care tests.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

cardiac surgery

cardiopulmonary bypass

protamine

heparin

point-of-care testing

statistical modeling

Publikations- och innehållstyp

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