Remobilization does not fully restore immobilization induced articular cartilage atrophy.

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Haapala, JussiDepartment of Surgery, Kuopio University Hospital, Kuopio, Finland; Department of Rehabilitation Clinic, Kuopio University Hospital, Kuopio, Finland (författare)

Remobilization does not fully restore immobilization induced articular cartilage atrophy.

Artikel/kapitelEngelska1999

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Lippincott Williams & Wilkins,1999
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LIBRIS-ID:oai:DiVA.org:umu-107631
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-107631URI

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Språk:engelska
Sammanfattning på:engelska &language:-1_t

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The recovery of articular cartilage from immobilization induced atrophy was studied. The right hind limbs of 29-week-old beagle dogs were immobilized for 11 weeks and then remobilized for 50 weeks. Cartilage from the immobilized knee was compared with tissue from age matched control animals. After the immobilization period, uncalcified articular cartilage glycosaminoglycan concentration was reduced by 20% to 23%, the reduction being largest (44%) in the superficial zone. The collagen fibril network showed no significant changes, but the amount of collagen crosslinks was reduced (13.5%) during immobilization. After remobilization, glycosaminoglycan concentration was restored at most sites, except for in the upper parts of uncalcified cartilage in the medial femoral and tibial condyles (9% to 17% less glycosaminoglycans than in controls). The incorporation of 35SO4 was not changed, and remobilization also did not alter the birefringence of collagen fibrils. Remobilization restored the proportion of collagen crosslinks to the control level. The changes induced by joint unloading were reversible at most sites investigated, but full restoration of articular cartilage glycosaminoglycan concentration was not obtained in all sites, even after remobilization for 50 weeks. This suggests that lengthy immobilization of a joint can cause long lasting articular cartilage proteoglycan alterations at the same time as collagen organization remains largely unchanged. Because proteoglycans exert strong influence on the biomechanical properties of cartilage, lengthy immobilization may jeopardize the well being of articular cartilage.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Ortopedi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Orthopaedics hsv//eng
NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
Articular cartilage
dog
immobilzation
remobilization
proteoglycans
biokemi
Biochemistry
ortopedi
Orthopaedics

Biuppslag (personer, institutioner, konferenser, titlar ...)

Arokoski, JariDepartment of Rehabilitation Clinic, Kuopio University Hospital, Kuopio, Finland (författare)
Hyttinen, MikaDepartment of Anatomy, University of Kuopio, Kuopio, Finland (författare)
Lammi, Mikko,1961-Department of Anatomy, University of Kuopio, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group(Swepub:umu)mila0077 (författare)
Tammi, MarkkuDepartment of Anatomy, University of Kuopio, Kuopio, Finland (författare)
Kovanen, VuokkoDepartment of Health Sciences, University of Jyväskylä, Jyväskylä, Finland (författare)
Helminen, HeikkiDepartment of Anatomy, University of Kuopio, Kuopio, Finland (författare)
Kiviranta, IlkkaDepartment of Surgery, Jyväskylä Central Hospital, Jyväskylä, Finland (författare)
Department of Surgery, Kuopio University Hospital, Kuopio, Finland; Department of Rehabilitation Clinic, Kuopio University Hospital, Kuopio, FinlandDepartment of Rehabilitation Clinic, Kuopio University Hospital, Kuopio, Finland (creator_code:org_t)

Sammanhörande titlar

Ingår i:Clinical Orthopaedics and Related Research: Lippincott Williams & Wilkins:362, s. 218-2290009-921X1528-1132

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Clinical Orthopaedics and Related Research (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Haapala, Jussi; Arokoski, Jari; Hyttinen, Mika; Lammi, Mikko, 19 ...; Tammi, Markku; Kovanen, Vuokko; visa fler...; Helminen, Heikki; Kiviranta, Ilkka; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Ortopedi

NATURVETENSKAP: NATURVETENSKAP; och Biologi; och Biokemi och mole ...

Artiklar i publikationen: Clinical Orthopa ...

Av lärosätet: Umeå universitet

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