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Organoid models of ...
Organoid models of human and mouse ductal pancreatic cancer
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Boj, Sylvia F (author)
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Hwang, Chang-Il (author)
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Baker, Lindsey A (author)
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Chio, Iok In Christine (author)
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Engle, Dannielle D (author)
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Corbo, Vincenzo (author)
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Jager, Myrthe (author)
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Ponz-Sarvise, Mariano (author)
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Tiriac, Hervé (author)
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Spector, Mona S (author)
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Gracanin, Ana (author)
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Oni, Tobiloba (author)
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Yu, Kenneth H (author)
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van Boxtel, Ruben (author)
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Huch, Meritxell (author)
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Rivera, Keith D (author)
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Wilson, John P (author)
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Feigin, Michael E (author)
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Öhlund, Daniel, 1979- (author)
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Handly-Santana, Abram (author)
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Ardito-Abraham, Christine M (author)
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Ludwig, Michael (author)
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Elyada, Ela (author)
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Alagesan, Brinda (author)
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Biffi, Giulia (author)
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Yordanov, Georgi N (author)
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Delcuze, Bethany (author)
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Creighton, Brianna (author)
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Wright, Kevin (author)
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Park, Youngkyu (author)
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Morsink, Folkert HM (author)
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Molenaar, I Quintus (author)
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Borel Rinkes, Inne H (author)
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Cuppen, Edwin (author)
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Hao, Yuan (author)
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Jin, Ying (author)
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Nijman, Isaac J (author)
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Iacobuzio-Donahue, Christine (author)
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Leach, Steven D (author)
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Pappin, Darryl J (author)
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Hammell, Molly (author)
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Klimstra, David S (author)
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Basturk, Olca (author)
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Hruban, Ralph H (author)
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Offerhaus, George Johan (author)
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Vries, Robert GJ (author)
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Clevers, Hans (author)
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Tuveson, David A (author)
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- Cell press, 2015
- 2015
- English.
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In: Cell. - : Cell press. - 0092-8674 .- 1097-4172. ; 160:1-2, s. 324-338
- Related links:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited response to treatment. Tractable methods to identify and interrogate pathways involved in pancreatic tumorigenesis are urgently needed. We established organoid models from normal and neoplastic murine and human pancreas tissues. Pancreatic organoids can be rapidly generated from resected tumors and biopsies, survive cryopreservation, and exhibit ductal- and disease-stage-specific characteristics. Orthotopically transplanted neoplastic organoids recapitulate the full spectrum of tumor development by forming early-grade neoplasms that progress to locally invasive and metastatic carcinomas. Due to their ability to be genetically manipulated, organoids are a platform to probe genetic cooperation. Comprehensive transcriptional and proteomic analyses of murine pancreatic organoids revealed genes and pathways altered during disease progression. The confirmation of many of these protein changes in human tissues demonstrates that organoids are a facile model system to discover characteristics of this deadly malignancy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- acinar-cell transdifferentiation
- in-vitro expansion
- oncogenic kras
- expression profiles
- progenitor cells
- adenocarcinoma
- mice
- neoplasia
- promotes
- identification
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cell
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To the university's database
- By the author/editor
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Boj, Sylvia F
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Hwang, Chang-Il
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Baker, Lindsey A
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Chio, Iok In Chr ...
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Engle, Dannielle ...
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Corbo, Vincenzo
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show more...
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Jager, Myrthe
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Ponz-Sarvise, Ma ...
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Tiriac, Hervé
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Spector, Mona S
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Gracanin, Ana
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Oni, Tobiloba
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Yu, Kenneth H
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van Boxtel, Rube ...
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Huch, Meritxell
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Rivera, Keith D
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Wilson, John P
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Feigin, Michael ...
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Öhlund, Daniel, ...
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Handly-Santana, ...
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Ardito-Abraham, ...
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Ludwig, Michael
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Elyada, Ela
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Alagesan, Brinda
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Biffi, Giulia
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Yordanov, Georgi ...
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Delcuze, Bethany
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Creighton, Brian ...
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Wright, Kevin
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Park, Youngkyu
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Morsink, Folkert ...
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Molenaar, I Quin ...
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Borel Rinkes, In ...
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Cuppen, Edwin
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Hao, Yuan
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Jin, Ying
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Nijman, Isaac J
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Iacobuzio-Donahu ...
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Leach, Steven D
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Pappin, Darryl J
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Hammell, Molly
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Klimstra, David ...
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Basturk, Olca
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Hruban, Ralph H
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Offerhaus, Georg ...
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Vries, Robert GJ
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Clevers, Hans
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Tuveson, David A
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Cell
- By the university
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Umeå University