The clinical dilemma of quantifying mechanical left ventricular dyssynchrony for cardiac resynchronization therapy: segmental or global?

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Bajraktari, GaniUmeå universitet,Kardiologi,University Clinical Center of Kosova, University of Prishtina, Republic of Kosovo (author)

The clinical dilemma of quantifying mechanical left ventricular dyssynchrony for cardiac resynchronization therapy : segmental or global?

Article/chapterEnglish2015

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2014-09-23
Wiley,2015
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LIBRIS-ID:oai:DiVA.org:umu-101975
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-101975URI
https://doi.org/10.1111/echo.12775DOI

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Language:English
Summary in:English

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Subject category:for swepub-publicationtype

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Heart failure (HF) represents a serious clinical and public cause of mortality, morbidity, as well as healthcare expenditures. Guidelines for treatment of HF join in recommending multimedical regimen at targeted doses as the best medical strategy, despite that a significant percentage of patients remain symptomatic. Studies have shown that these patients might benefit from cardiac resynchronization therapy (CRT), particularly those presenting with broad QRS duration, >135 msec. Trials have already shown that CRT results in improved morbidity and survival of these patients particularly those in New York Heart Association class III-IV HF, but almost 30% do not show any symptomatic or survival benefit, hence are classified as nonresponders. Exhaustive efforts have been made in using noninvasive methods of assessing left ventricle (LV) dyssynchrony in predicting nonresponders to CRT, including Doppler echocardiography, magnetic resonance imaging, and even single photon emission computed tomography analysis, but only with modest success. In this report, we aimed to review the available evidence for assessing markers of mechanical LV dyssynchrony by various echocardiographic modalities and their respective strength in predicting favorable response to CRT treatment, comparing global with segmental ones. While the accuracy of segmental markers of dyssynchrony in predicting satisfactory response to CRT remains controversial because of various technical limitations, global markers seem easier to measure, reproducible, and potentially accurate in reflecting overall cavity response and its clinical implications. More studies are needed to qualify this proposal.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
cardiac imaging
Doppler echocardiography
heart failure
cardiac resynchronization therapy

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Henein, Michael YUmeå universitet,Kardiologi,Heart Center(Swepub:umu)mihe0015 (author)
Umeå universitetKardiologi (creator_code:org_t)

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In:Echocardiography: Wiley32:1, s. 150-1550742-28221540-8175

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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